node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DOHH | SLMO2 | ENSP00000250937 | ENSP00000348206 | deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor | slowmo homolog 2 (Drosophila) | 0.628 |
DOHH | UBC | ENSP00000250937 | ENSP00000344818 | deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor | ubiquitin C | 0.509 |
ELAVL1 | UBC | ENSP00000385269 | ENSP00000344818 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | ubiquitin C | 0.998 |
FARS2 | FARSA | ENSP00000274680 | ENSP00000320309 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | phenylalanyl-tRNA synthetase, alpha subunit | 0.947 |
FARS2 | FARSB | ENSP00000274680 | ENSP00000281828 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | phenylalanyl-tRNA synthetase, beta subunit | 0.988 |
FARS2 | LRRC47 | ENSP00000274680 | ENSP00000367498 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | leucine rich repeat containing 47 | 0.941 |
FARS2 | PHB | ENSP00000274680 | ENSP00000300408 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging | 0.629 |
FARS2 | PHB2 | ENSP00000274680 | ENSP00000441875 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.605 |
FARS2 | PRELID1 | ENSP00000274680 | ENSP00000302114 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | PRELI domain containing 1; May be important for the development of vital and immunocompetent organs | 0.950 |
FARS2 | SLMO2 | ENSP00000274680 | ENSP00000348206 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | slowmo homolog 2 (Drosophila) | 0.780 |
FARS2 | STOML1 | ENSP00000274680 | ENSP00000319323 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | stomatin (EPB72)-like 1 | 0.693 |
FARS2 | TRIAP1 | ENSP00000274680 | ENSP00000449795 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | TP53 regulated inhibitor of apoptosis 1; Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis | 0.871 |
FARS2 | UBC | ENSP00000274680 | ENSP00000344818 | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | ubiquitin C | 0.483 |
FARSA | FARS2 | ENSP00000320309 | ENSP00000274680 | phenylalanyl-tRNA synthetase, alpha subunit | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | 0.947 |
FARSA | FARSB | ENSP00000320309 | ENSP00000281828 | phenylalanyl-tRNA synthetase, alpha subunit | phenylalanyl-tRNA synthetase, beta subunit | 0.999 |
FARSA | LRRC47 | ENSP00000320309 | ENSP00000367498 | phenylalanyl-tRNA synthetase, alpha subunit | leucine rich repeat containing 47 | 0.976 |
FARSA | PRELID1 | ENSP00000320309 | ENSP00000302114 | phenylalanyl-tRNA synthetase, alpha subunit | PRELI domain containing 1; May be important for the development of vital and immunocompetent organs | 0.475 |
FARSA | UBC | ENSP00000320309 | ENSP00000344818 | phenylalanyl-tRNA synthetase, alpha subunit | ubiquitin C | 0.959 |
FARSB | FARS2 | ENSP00000281828 | ENSP00000274680 | phenylalanyl-tRNA synthetase, beta subunit | phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins | 0.988 |
FARSB | FARSA | ENSP00000281828 | ENSP00000320309 | phenylalanyl-tRNA synthetase, beta subunit | phenylalanyl-tRNA synthetase, alpha subunit | 0.999 |