node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERAL1 | SLC25A46 | ENSP00000254928 | ENSP00000348211 | Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly | solute carrier family 25, member 46 | 0.670 |
ERAL1 | UBC | ENSP00000254928 | ENSP00000344818 | Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly | ubiquitin C | 0.484 |
FHL3 | UBC | ENSP00000362107 | ENSP00000344818 | four and a half LIM domains 3 | ubiquitin C | 0.925 |
FUNDC1 | SLC25A46 | ENSP00000367284 | ENSP00000348211 | FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | solute carrier family 25, member 46 | 0.531 |
FUNDC1 | UBC | ENSP00000367284 | ENSP00000344818 | FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | ubiquitin C | 0.483 |
LAMTOR1 | SLC25A46 | ENSP00000278671 | ENSP00000348211 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible [...] | solute carrier family 25, member 46 | 0.644 |
LAMTOR1 | UBC | ENSP00000278671 | ENSP00000344818 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible [...] | ubiquitin C | 0.971 |
MARC1 | SLC25A46 | ENSP00000355877 | ENSP00000348211 | mitochondrial amidoxime reducing component 1 | solute carrier family 25, member 46 | 0.644 |
MARC1 | UBC | ENSP00000355877 | ENSP00000344818 | mitochondrial amidoxime reducing component 1 | ubiquitin C | 0.860 |
SCFD1 | SLC25A46 | ENSP00000390783 | ENSP00000348211 | sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) | solute carrier family 25, member 46 | 0.644 |
SCFD1 | UBC | ENSP00000390783 | ENSP00000344818 | sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) | ubiquitin C | 0.831 |
SLC25A46 | ERAL1 | ENSP00000348211 | ENSP00000254928 | solute carrier family 25, member 46 | Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly | 0.670 |
SLC25A46 | FUNDC1 | ENSP00000348211 | ENSP00000367284 | solute carrier family 25, member 46 | FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | 0.531 |
SLC25A46 | LAMTOR1 | ENSP00000348211 | ENSP00000278671 | solute carrier family 25, member 46 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible [...] | 0.644 |
SLC25A46 | MARC1 | ENSP00000348211 | ENSP00000355877 | solute carrier family 25, member 46 | mitochondrial amidoxime reducing component 1 | 0.644 |
SLC25A46 | SCFD1 | ENSP00000348211 | ENSP00000390783 | solute carrier family 25, member 46 | sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) | 0.644 |
SLC25A46 | UBC | ENSP00000348211 | ENSP00000344818 | solute carrier family 25, member 46 | ubiquitin C | 0.620 |
UBC | ERAL1 | ENSP00000344818 | ENSP00000254928 | ubiquitin C | Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly | 0.484 |
UBC | FHL3 | ENSP00000344818 | ENSP00000362107 | ubiquitin C | four and a half LIM domains 3 | 0.925 |
UBC | FUNDC1 | ENSP00000344818 | ENSP00000367284 | ubiquitin C | FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control | 0.483 |