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NUFIP2 NUFIP2 CLNS1A CLNS1A NUP188 NUP188 EIF4G1 EIF4G1 PDPK1 PDPK1 DHX40 DHX40 PDK1 PDK1 USP10 USP10 TMA16 TMA16 SCT SCT DHX8 DHX8 NOL6 NOL6 G3BP1 G3BP1 UBC UBC ULK1 ULK1 HAT1 HAT1 CAPRIN1 CAPRIN1 IFRD2 IFRD2 FAF1 FAF1 YTHDF1 YTHDF1 RIOK2 RIOK2 KRI1 KRI1 RPAP2 RPAP2 HIST2H2AA3 HIST2H2AA3 ATXN2L ATXN2L FLNB FLNB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SCTsecretin; Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach (121 aa)
USP10ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...] (798 aa)
NUFIP2nuclear fragile X mental retardation protein interacting protein 2; Binds RNA (695 aa)
DHX40DEAH (Asp-Glu-Ala-His) box polypeptide 40; Probable ATP-dependent RNA helicase (By similarity) (779 aa)
DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (1220 aa)
HAT1histone acetyltransferase 1; Acetylates soluble but not nucleosomal histone H4 at ’Lys-5’ (H4K5ac) and ’Lys-12’ (H4K12ac) and, to a lesser extent, acetylates histone H2A at ’Lys-5’ (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage (419 aa)
PDK1pyruvate dehydrogenase kinase, isozyme 1; Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apopt [...] (436 aa)
RIOK2RIO kinase 2 (yeast) (552 aa)
NOL6nucleolar protein family 6 (RNA-associated) (1146 aa)
KRI1KRI1 homolog (S. cerevisiae) (709 aa)
ULK1unc-51-like kinase 1 (C. elegans); Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading [...] (1050 aa)
EIF4G1eukaryotic translation initiation factor 4 gamma, 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome (1606 aa)
CAPRIN1cell cycle associated protein 1; May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (By similarity) (709 aa)
PDPK13-phosphoinositide dependent protein kinase-1; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include- protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central rol [...] (556 aa)
UBCubiquitin C (685 aa)
G3BP1GTPase activating protein (SH3 domain) binding protein 1; May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3’-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3’ tail or hanging tails at both 5’- and 3’-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in [...] (466 aa)
TMA16translation machinery associated 16 homolog (S. cerevisiae) (203 aa)
HIST2H2AA3histone cluster 2, H2aa3 (130 aa)
YTHDF1YTH domain family, member 1 (559 aa)
RPAP2RNA polymerase II associated protein 2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated ’Ser-7’ of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of ’Ser-5’ of the CTD, thereby promoting transcription of snRNA genes (612 aa)
FAF1Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis (650 aa)
NUP188nucleoporin 188kDa; May function as a component of the nuclear pore complex (NPC) (1749 aa)
ATXN2Lataxin 2-like (1097 aa)
IFRD2interferon-related developmental regulator 2 (506 aa)
FLNBfilamin B, beta (2633 aa)
CLNS1Achloride channel, nucleotide-sensitive, 1A; The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway (237 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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