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RPL27 RPL27 ANKRD31 ANKRD31 TOPBP1 TOPBP1 CAD CAD PPWD1 PPWD1 UMPS UMPS ACAT1 ACAT1 PSMD3 PSMD3 ACAT2 ACAT2 HADHB HADHB UBC UBC ZNF830 ZNF830 HADHA HADHA EHHADH EHHADH ECHS1 ECHS1 ANKRD32 ANKRD32 PEX5L PEX5L HSD17B4 HSD17B4 GCDH GCDH ACAA2 ACAA2 CPT2 CPT2 PEX5 PEX5 ACOX3 ACOX3 ACAA1 ACAA1 AMACR AMACR ACSBG2 ACSBG2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
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GCDHglutaryl-CoA dehydrogenase; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive (438 aa)
EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
UMPSuridine monophosphate synthetase (480 aa)
ACSBG2acyl-CoA synthetase bubblegum family member 2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis (666 aa)
RPL27ribosomal protein L27 (136 aa)
TOPBP1topoisomerase (DNA) II binding protein 1; Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1- responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (1522 aa)
PPWD1peptidylprolyl isomerase domain and WD repeat containing 1; Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (646 aa)
PSMD3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (534 aa)
CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
ANKRD32ankyrin repeat domain 32 (1058 aa)
ACAT1acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism (427 aa)
ANKRD31ankyrin repeat domain 31 (1873 aa)
ACAA2acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (474 aa)
ACAA1acetyl-CoA acyltransferase 1 (424 aa)
UBCubiquitin C (685 aa)
ACOX3acyl-CoA oxidase 3, pristanoyl; Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity) (700 aa)
ZNF830zinc finger protein 830; May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity) (372 aa)
ACAT2acetyl-CoA acetyltransferase 2 (397 aa)
ECHS1enoyl CoA hydratase, short chain, 1, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (290 aa)
CPT2carnitine palmitoyltransferase 2 (658 aa)
HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit (763 aa)
AMACRalpha-methylacyl-CoA racemase (394 aa)
PEX5peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import (654 aa)
PEX5Lperoxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity) (626 aa)
HSD17B4hydroxysteroid (17-beta) dehydrogenase 4; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids (761 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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