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NAE1 NAE1 FBP1 FBP1 FBP2 FBP2 WDR45 WDR45 BECN1 BECN1 UBA2 UBA2 ATG2B ATG2B ATG2A ATG2A SAE1 SAE1 WIPI1 WIPI1 WIPI2 WIPI2 ATG7 ATG7 MOCS3 MOCS3 PWP2 PWP2 STX7 STX7 UTP18 UTP18 STX12 STX12 TBL3 TBL3 TSNARE1 TSNARE1 UTP6 UTP6 WDR36 WDR36 STX16 STX16 STX17 STX17 WDR3 WDR3 ENSG00000254995 ENSG00000254995 ENSG00000248354 ENSG00000248354
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UTP18UTP18 small subunit (SSU) processome component homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (556 aa)
MOCS3molybdenum cofactor synthesis 3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the [...] (460 aa)
UBA2ubiquitin-like modifier activating enzyme 2; The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (640 aa)
STX17syntaxin 17; SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediat [...] (302 aa)
UTP6UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (597 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] (446 aa)
SAE1SUMO1 activating enzyme subunit 1; The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (346 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P (454 aa)
NAE1NEDD8 activating enzyme E1 subunit 1; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (534 aa)
PWP2PWP2 periodic tryptophan protein homolog (yeast) (919 aa)
TSNARE1t-SNARE domain containing 1 (513 aa)
WDR3WD repeat domain 3 (943 aa)
ATG7autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) (703 aa)
WDR45WD repeat domain 45 (361 aa)
ATG2Bautophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (2078 aa)
BECN1beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus (450 aa)
STX7syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (261 aa)
STX16syntaxin 16 (325 aa)
STX12syntaxin 12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity) (276 aa)
FBP1fructose-1,6-bisphosphatase 1 (338 aa)
FBP2fructose-1,6-bisphosphatase 2 (339 aa)
ATG2Aautophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion (1938 aa)
ENSG00000248354Uncharacterized protein (205 aa)
WDR36WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 (951 aa)
TBL3transducin (beta)-like 3 (808 aa)
ENSG00000254995STX16-NPEPL1 readthrough (non-protein coding) (382 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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