node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG2A | ATG2B | ENSP00000366475 | ENSP00000353010 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.621 |
ATG2A | ATG7 | ENSP00000366475 | ENSP00000346437 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.624 |
ATG2A | BECN1 | ENSP00000366475 | ENSP00000355231 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.634 |
ATG2A | WDR45 | ENSP00000366475 | ENSP00000348848 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain 45 | 0.790 |
ATG2A | WIPI1 | ENSP00000366475 | ENSP00000262139 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] | 0.997 |
ATG2A | WIPI2 | ENSP00000366475 | ENSP00000288828 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.988 |
ATG2B | ATG2A | ENSP00000353010 | ENSP00000366475 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.621 |
ATG2B | ATG7 | ENSP00000353010 | ENSP00000346437 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.665 |
ATG2B | BECN1 | ENSP00000353010 | ENSP00000355231 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.680 |
ATG2B | WDR45 | ENSP00000353010 | ENSP00000348848 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain 45 | 0.999 |
ATG2B | WIPI1 | ENSP00000353010 | ENSP00000262139 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] | 0.986 |
ATG2B | WIPI2 | ENSP00000353010 | ENSP00000288828 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.985 |
ATG7 | ATG2A | ENSP00000346437 | ENSP00000366475 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.624 |
ATG7 | ATG2B | ENSP00000346437 | ENSP00000353010 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.665 |
ATG7 | BECN1 | ENSP00000346437 | ENSP00000355231 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.972 |
ATG7 | MOCS3 | ENSP00000346437 | ENSP00000244051 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | molybdenum cofactor synthesis 3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the [...] | 0.528 |
ATG7 | UBA1 | ENSP00000346437 | ENSP00000338413 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | ubiquitin-like modifier activating enzyme 1; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP | 0.593 |
ATG7 | UBA6 | ENSP00000346437 | ENSP00000313454 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | ubiquitin-like modifier activating enzyme 6 | 0.509 |
ATG7 | WDR45 | ENSP00000346437 | ENSP00000348848 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | WD repeat domain 45 | 0.601 |
ATG7 | WIPI1 | ENSP00000346437 | ENSP00000262139 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] | 0.886 |