Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | OTUB2 | OTU domain, ubiquitin aldehyde binding 2; Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains, with a preference for ’Lys-63’-linked polyubiquitin chains (234 aa) | ||
 | SNRPC | small nuclear ribonucleoprotein polypeptide C; Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region (159 aa) | ||
 | NAF1 | nuclear assembly factor 1 homolog (S. cerevisiae); RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (494 aa) | ||
 | UBASH3B | ubiquitin associated and SH3 domain containing B; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination (649 aa) | ||
 | FAM105B | family with sequence similarity 105, member B (352 aa) | ||
 | VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (355 aa) | ||
 | RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (418 aa) | ||
 | TNIP1 | TNFAIP3 interacting protein 1; Interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal; however, binding to A20/TNFAIP3 seems not to be required for this function (By similarity). Inhibits NF-kappa-B activation by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcricption. [...] (636 aa) | ||
 | R3HDM2 | R3H domain containing 2 (976 aa) | ||
 | DTX2 | deltex homolog 2 (Drosophila); Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (622 aa) | ||
 | SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 (396 aa) | ||
 | RBPMS | RNA binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA (219 aa) | ||
 | UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 (170 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | FAM168A | family with sequence similarity 168, member A (235 aa) | ||
 | BAG3 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity (575 aa) | ||
 | DAB1 | disabled homolog 1 (Drosophila) (555 aa) | ||
 | SMAP2 | small ArfGAP2 (429 aa) | ||
 | SF1 | splicing factor 1 (673 aa) | ||
 | PRR20A | proline rich 20A (221 aa) | ||
 | KLHDC5 | kelch domain containing 5; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis (505 aa) | ||
 | TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (789 aa) | ||
 | C1orf94 | chromosome 1 open reading frame 94 (598 aa) | ||
 | DAZAP2 | DAZ associated protein 2 (207 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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