node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATRAID | NELL1 | ENSP00000369518 | ENSP00000349654 | all-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.582 |
DNTTIP2 | NELL1 | ENSP00000411010 | ENSP00000349654 | deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.518 |
DNTTIP2 | NOL10 | ENSP00000411010 | ENSP00000371101 | deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein | nucleolar protein 10 | 0.541 |
EEF1A1 | EGFR | ENSP00000330054 | ENSP00000275493 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | epidermal growth factor receptor | 0.618 |
EEF1A1 | EIF5B | ENSP00000330054 | ENSP00000289371 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | eukaryotic translation initiation factor 5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity) | 0.617 |
EEF1A1 | NELL1 | ENSP00000330054 | ENSP00000349654 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.558 |
EEF1A1 | PLCG1 | ENSP00000330054 | ENSP00000244007 | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.822 |
EGFR | EEF1A1 | ENSP00000275493 | ENSP00000330054 | epidermal growth factor receptor | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | 0.618 |
EGFR | PLCG1 | ENSP00000275493 | ENSP00000244007 | epidermal growth factor receptor | phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration | 0.999 |
EIF4B | EIF5B | ENSP00000262056 | ENSP00000289371 | eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5’- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F | eukaryotic translation initiation factor 5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity) | 0.956 |
EIF4B | NELL1 | ENSP00000262056 | ENSP00000349654 | eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5’- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.512 |
EIF5B | EEF1A1 | ENSP00000289371 | ENSP00000330054 | eukaryotic translation initiation factor 5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity) | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | 0.617 |
EIF5B | EIF4B | ENSP00000289371 | ENSP00000262056 | eukaryotic translation initiation factor 5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity) | eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5’- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F | 0.956 |
EIF5B | NELL1 | ENSP00000289371 | ENSP00000349654 | eukaryotic translation initiation factor 5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity) | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | 0.512 |
NELL1 | ATRAID | ENSP00000349654 | ENSP00000369518 | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | all-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway | 0.582 |
NELL1 | DNTTIP2 | ENSP00000349654 | ENSP00000411010 | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein | 0.518 |
NELL1 | EEF1A1 | ENSP00000349654 | ENSP00000330054 | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production | 0.558 |
NELL1 | EIF4B | ENSP00000349654 | ENSP00000262056 | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5’- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F | 0.512 |
NELL1 | EIF5B | ENSP00000349654 | ENSP00000289371 | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | eukaryotic translation initiation factor 5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity) | 0.512 |
NELL1 | NEXN | ENSP00000349654 | ENSP00000333938 | NEL-like 1 (chicken); Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization | nexilin (F actin binding protein) | 0.514 |