Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | OSGEP | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) (335 aa) | ||
 | MAGED2 | melanoma antigen family D, 2 (606 aa) | ||
 | RNF114 | ring finger protein 114; May play a role in spermatogenesis (228 aa) | ||
 | TCEB2 | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (161 aa) | ||
 | PTPN23 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (1636 aa) | ||
 | SNRPF | small nuclear ribonucleoprotein polypeptide F; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Associated with snRNP U1, U2, U4/U6 and U5 (86 aa) | ||
 | GINS4 | GINS complex subunit 4 (Sld5 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA (223 aa) | ||
 | OGFR | opioid growth factor receptor (677 aa) | ||
 | MT1A | metallothionein 1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids (61 aa) | ||
 | PDE9A | phosphodiesterase 9A (593 aa) | ||
 | RNF214 | ring finger protein 214 (703 aa) | ||
 | RPAP1 | RNA polymerase II associated protein 1; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (1393 aa) | ||
 | PTMS | parathymosin; Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections (102 aa) | ||
 | SSSCA1 | Sjogren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies (199 aa) | ||
 | MCFD2 | multiple coagulation factor deficiency 2; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors (146 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | NDRG3 | NDRG family member 3 (375 aa) | ||
 | ZFYVE19 | zinc finger, FYVE domain containing 19 (471 aa) | ||
 | LAGE3 | L antigen family, member 3 (143 aa) | ||
 | RAB5B | RAB5B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (215 aa) | ||
 | AHCYL1 | adenosylhomocysteinase-like 1 (530 aa) | ||
 | TP53RK | TP53 regulating kinase; Protein kinase that phosphorylates ’Ser-15’ of p53/TP53 protein and may therefore participate in its activation (253 aa) | ||
 | TOM1L2 | target of myb1-like 2 (chicken); Probable role in protein transport. May regulate growth factor-induced mitogenic signaling (507 aa) | ||
 | USP34 | ubiquitin specific peptidase 34 (3546 aa) | ||
 | PUM1 | pumilio homolog 1 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity) (1188 aa) | ||
 | SEPHS2 | selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP (448 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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