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ABHD11 | abhydrolase domain containing 11 (315 aa) | |||
RNF103 | ring finger protein 103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway (685 aa) | |||
NR1H2 | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) (460 aa) | |||
EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) (455 aa) | |||
ABHD10 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate (306 aa) | |||
ABHD14A | abhydrolase domain containing 14A; Possible role in granule neuron development (By similarity) (271 aa) | |||
PPME1 | protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (386 aa) | |||
SERHL2 | serine hydrolase-like 2; Probable serine hydrolase. May be related to cell muscle hypertrophy (314 aa) | |||
LIPA | lipase A, lysosomal acid, cholesterol esterase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation (399 aa) | |||
SLC29A2 | solute carrier family 29 (nucleoside transporters), member 2; Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine (456 aa) | |||
ABHD14B | abhydrolase domain containing 14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription (210 aa) | |||
LIPJ | lipase, family member J (366 aa) | |||
LIPF | lipase, gastric (408 aa) | |||
LIPK | lipase, family member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (399 aa) | |||
LIPM | lipase, family member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (423 aa) | |||
LIPN | lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (398 aa) | |||
ABHD5 | abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation (349 aa) | |||
ENSG00000249884 | RNF103-CHMP3 readthrough (221 aa) | |||
CHMP3 | charged multivesicular body protein 3 (251 aa) | |||
ABHD4 | abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...] (342 aa) |