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KANK1 KANK1 ENSG00000250021 ENSG00000250021 SOWAHC SOWAHC PIDD PIDD SOX2 SOX2 ASB8 ASB8 TNKS TNKS ANKRD53 ANKRD53 TNKS2 TNKS2 CASKIN2 CASKIN2 ANKDD1B ANKDD1B NRARP NRARP POTEI POTEI ANKRD54 ANKRD54 C15orf38 C15orf38 ANKRD22 ANKRD22 ANKRD9 ANKRD9 POTEC POTEC ARPC2 ARPC2 ASB1 ASB1 ASB18 ASB18 CASKIN1 CASKIN1 ANKRD55 ANKRD55 PPP1R27 PPP1R27 ANKRD60 ANKRD60 ANKRD63 ANKRD63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ANKRD54ankyrin repeat domain 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation (By similarity) (300 aa)
ASB1ankyrin repeat and SOCS box containing 1; May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (335 aa)
ANKRD9ankyrin repeat domain 9 (317 aa)
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (300 aa)
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequ [...] (1327 aa)
ASB8ankyrin repeat and SOCS box containing 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (288 aa)
SOX2SRY (sex determining region Y)-box 2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiat [...] (317 aa)
CASKIN2CASK interacting protein 2 (1202 aa)
PPP1R27protein phosphatase 1, regulatory subunit 27; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes (154 aa)
PIDDp53-induced death domain protein (910 aa)
ANKRD55ankyrin repeat domain 55 (614 aa)
CASKIN1CASK interacting protein 1; May link the scaffolding protein CASK to downstream intracellular effectors (By similarity) (1431 aa)
NRARPNOTCH-regulated ankyrin repeat protein; May play a role in the formation of somites (By similarity) (114 aa)
C15orf38chromosome 15 open reading frame 38 (226 aa)
POTECPOTE ankyrin domain family, member C (542 aa)
ANKRD53ankyrin repeat domain 53 (530 aa)
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex- poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subseque [...] (1166 aa)
ANKRD22ankyrin repeat domain 22 (191 aa)
SOWAHCsosondowah ankyrin repeat domain family member C (525 aa)
KANK1KN motif and ankyrin repeat domains 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell sp [...] (1352 aa)
ENSG00000250021C15orf38-AP3S2 readthrough (394 aa)
ASB18ankyrin repeat and SOCS box containing 18; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (466 aa)
POTEIPOTE ankyrin domain family, member I (1075 aa)
ANKRD60ankyrin repeat domain 60 (345 aa)
ANKRD63ankyrin repeat domain 63 (380 aa)
ANKDD1Bankyrin repeat and death domain containing 1B (528 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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