node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJA3 | EGFR | ENSP00000262375 | ENSP00000275493 | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | epidermal growth factor receptor | 0.800 |
DNAJA3 | UBC | ENSP00000262375 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | ubiquitin C | 0.758 |
DNAJC16 | UBC | ENSP00000365007 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily C, member 16 | ubiquitin C | 0.541 |
DNAJC3 | UBC | ENSP00000365991 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | ubiquitin C | 0.752 |
EGFR | DNAJA3 | ENSP00000275493 | ENSP00000262375 | epidermal growth factor receptor | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | 0.800 |
EGFR | NEDD8 | ENSP00000275493 | ENSP00000250495 | epidermal growth factor receptor | neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins | 0.639 |
EGFR | UBC | ENSP00000275493 | ENSP00000344818 | epidermal growth factor receptor | ubiquitin C | 0.999 |
NAGLU | UBC | ENSP00000225927 | ENSP00000344818 | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | ubiquitin C | 0.620 |
NEDD8 | EGFR | ENSP00000250495 | ENSP00000275493 | neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins | epidermal growth factor receptor | 0.639 |
NEDD8 | UBC | ENSP00000250495 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins | ubiquitin C | 0.999 |
TOR4A | UBC | ENSP00000350102 | ENSP00000344818 | torsin family 4, member A | ubiquitin C | 0.702 |
UBC | DNAJA3 | ENSP00000344818 | ENSP00000262375 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | 0.758 |
UBC | DNAJC16 | ENSP00000344818 | ENSP00000365007 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily C, member 16 | 0.541 |
UBC | DNAJC3 | ENSP00000344818 | ENSP00000365991 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | 0.752 |
UBC | EGFR | ENSP00000344818 | ENSP00000275493 | ubiquitin C | epidermal growth factor receptor | 0.999 |
UBC | NAGLU | ENSP00000344818 | ENSP00000225927 | ubiquitin C | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | 0.620 |
UBC | NEDD8 | ENSP00000344818 | ENSP00000250495 | ubiquitin C | neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins | 0.999 |
UBC | TOR4A | ENSP00000344818 | ENSP00000350102 | ubiquitin C | torsin family 4, member A | 0.702 |