node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACY3 | ASPA | ENSP00000255082 | ENSP00000263080 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.916 |
ACY3 | FOLH1 | ENSP00000255082 | ENSP00000256999 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | folate hydrolase (prostate-specific membrane antigen) 1; Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity (By similarity) | 0.900 |
ACY3 | NAT8L | ENSP00000255082 | ENSP00000413064 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | N-acetyltransferase 8-like (GCN5-related, putative); Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake | 0.800 |
ACY3 | RIMKLA | ENSP00000255082 | ENSP00000414330 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | ribosomal modification protein rimK-like family member A; Catalyzes the synthesis of N-acetylaspartyl-glutamate (NAAG) | 0.900 |
ACY3 | RIMKLB | ENSP00000255082 | ENSP00000350136 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | ribosomal modification protein rimK-like family member B; Catalyzes the synthesis of beta-citryl-glutamate and N- acetyl-aspartyl-glutamate. Beta-citryl-glutamate is synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity) | 0.900 |
ASPA | ACY3 | ENSP00000263080 | ENSP00000255082 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | 0.916 |
ASPA | FOLH1 | ENSP00000263080 | ENSP00000256999 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | folate hydrolase (prostate-specific membrane antigen) 1; Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity (By similarity) | 0.923 |
ASPA | NAT8L | ENSP00000263080 | ENSP00000413064 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | N-acetyltransferase 8-like (GCN5-related, putative); Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake | 0.854 |
ASPA | RIMKLA | ENSP00000263080 | ENSP00000414330 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | ribosomal modification protein rimK-like family member A; Catalyzes the synthesis of N-acetylaspartyl-glutamate (NAAG) | 0.942 |
ASPA | RIMKLB | ENSP00000263080 | ENSP00000350136 | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | ribosomal modification protein rimK-like family member B; Catalyzes the synthesis of beta-citryl-glutamate and N- acetyl-aspartyl-glutamate. Beta-citryl-glutamate is synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity) | 0.920 |
CS | IDH1 | ENSP00000342056 | ENSP00000260985 | citrate synthase | isocitrate dehydrogenase 1 (NADP+), soluble | 0.890 |
CS | IDH2 | ENSP00000342056 | ENSP00000331897 | citrate synthase | isocitrate dehydrogenase 2 (NADP+), mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex | 0.904 |
CS | IDH3A | ENSP00000342056 | ENSP00000299518 | citrate synthase | isocitrate dehydrogenase 3 (NAD+) alpha | 0.947 |
CS | IDH3B | ENSP00000342056 | ENSP00000370223 | citrate synthase | isocitrate dehydrogenase 3 (NAD+) beta | 0.802 |
CS | MDH1 | ENSP00000342056 | ENSP00000438144 | citrate synthase | malate dehydrogenase 1, NAD (soluble) | 0.987 |
CS | MDH2 | ENSP00000342056 | ENSP00000327070 | citrate synthase | malate dehydrogenase 2, NAD (mitochondrial) | 0.996 |
CS | OGDHL | ENSP00000342056 | ENSP00000363216 | citrate synthase | oxoglutarate dehydrogenase-like | 0.621 |
CS | PC | ENSP00000342056 | ENSP00000377527 | citrate synthase | pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate | 0.985 |
CS | PCK1 | ENSP00000342056 | ENSP00000319814 | citrate synthase | phosphoenolpyruvate carboxykinase 1 (soluble); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle | 0.924 |
CS | RIMKLB | ENSP00000342056 | ENSP00000350136 | citrate synthase | ribosomal modification protein rimK-like family member B; Catalyzes the synthesis of beta-citryl-glutamate and N- acetyl-aspartyl-glutamate. Beta-citryl-glutamate is synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity) | 0.810 |