5 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

large nodes:
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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Predicted Interactions

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Your Input:
	ESR1	estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] (595 aa)
	RFX2	regulatory factor X, 2 (influences HLA class II expression) (723 aa)
	RFX4	regulatory factor X, 4 (influences HLA class II expression) (744 aa)
	GPS2	G protein pathway suppressor 2; Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (327 aa)
	RFX3	regulatory factor X, 3 (influences HLA class II expression) (749 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	RFX4	ENSP00000206249	ENSP00000350552	estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...]	regulatory factor X, 4 (influences HLA class II expression)	0.698
GPS2	RFX4	ENSP00000370104	ENSP00000350552	G protein pathway suppressor 2; Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction	regulatory factor X, 4 (influences HLA class II expression)	0.422
RFX2	RFX4	ENSP00000306335	ENSP00000350552	regulatory factor X, 2 (influences HLA class II expression)	regulatory factor X, 4 (influences HLA class II expression)	0.658
RFX3	RFX4	ENSP00000371434	ENSP00000350552	regulatory factor X, 3 (influences HLA class II expression)	regulatory factor X, 4 (influences HLA class II expression)	0.663
RFX4	ESR1	ENSP00000350552	ENSP00000206249	regulatory factor X, 4 (influences HLA class II expression)	estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...]	0.698
RFX4	GPS2	ENSP00000350552	ENSP00000370104	regulatory factor X, 4 (influences HLA class II expression)	G protein pathway suppressor 2; Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction	0.422
RFX4	RFX2	ENSP00000350552	ENSP00000306335	regulatory factor X, 4 (influences HLA class II expression)	regulatory factor X, 2 (influences HLA class II expression)	0.658
RFX4	RFX3	ENSP00000350552	ENSP00000371434	regulatory factor X, 4 (influences HLA class II expression)	regulatory factor X, 3 (influences HLA class II expression)	0.663

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