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STRINGSTRING
EXOC7 EXOC7 KXD1 KXD1 IFT43 IFT43 WDR35 WDR35 ABI2 ABI2 IFT74 IFT74 WDR19 WDR19 IFT20 IFT20 IFT140 IFT140 IFT57 IFT57 TTC21B TTC21B IFT81 IFT81 IFT88 IFT88 ATRIP ATRIP KIF3B KIF3B IFT27 IFT27 IFT52 IFT52 IFT122 IFT122 FBF1 FBF1 DYNC2LI1 DYNC2LI1 HSPB11 HSPB11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
HSPB11heat shock protein family B (small), member 11 (144 aa)
KXD1KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) (176 aa)
IFT43intraflagellar transport 43 homolog (Chlamydomonas); Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (213 aa)
IFT81intraflagellar transport 81 homolog (Chlamydomonas); Isoform CDV-1 may be involved in cardiac hypertrophy caused by carnitine deficiency (By similarity) (676 aa)
TTC21Btetratricopeptide repeat domain 21B (1316 aa)
DYNC2LI1dynein, cytoplasmic 2, light intermediate chain 1 (351 aa)
ABI2abl-interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA (475 aa)
IFT57intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (429 aa)
IFT122intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) (1292 aa)
WDR35WD repeat domain 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis (1181 aa)
ATRIPATR interacting protein (791 aa)
IFT88intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity) (833 aa)
FBF1Fas (TNFRSF6) binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3 (1133 aa)
EXOC7exocyst complex component 7 (735 aa)
IFT20intraflagellar transport 20 homolog (Chlamydomonas); Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (148 aa)
IFT52intraflagellar transport 52 homolog (Chlamydomonas) (437 aa)
KIF3Bkinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) (747 aa)
IFT74intraflagellar transport 74 homolog (Chlamydomonas) (600 aa)
WDR19WD repeat domain 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity) (1342 aa)
IFT27intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) (186 aa)
IFT140intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance (1462 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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