node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRA1A | TLL2 | ENSP00000369960 | ENSP00000350630 | adrenoceptor alpha 1A | tolloid-like 2; Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.577 |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | BMP5 | ENSP00000368104 | ENSP00000359866 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 5; Induces cartilage and bone formation | 0.969 |
BMP2 | BMP6 | ENSP00000368104 | ENSP00000283147 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.709 |
BMP2 | BMP7 | ENSP00000368104 | ENSP00000379204 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.968 |
BMP2 | CHRD | ENSP00000368104 | ENSP00000204604 | bone morphogenetic protein 2; Induces cartilage and bone formation | chordin | 0.999 |
BMP2 | HSPG2 | ENSP00000368104 | ENSP00000363827 | bone morphogenetic protein 2; Induces cartilage and bone formation | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.845 |
BMP2 | TGFB1 | ENSP00000368104 | ENSP00000221930 | bone morphogenetic protein 2; Induces cartilage and bone formation | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.718 |
BMP2 | TLL2 | ENSP00000368104 | ENSP00000350630 | bone morphogenetic protein 2; Induces cartilage and bone formation | tolloid-like 2; Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.755 |
BMP3 | CHRD | ENSP00000282701 | ENSP00000204604 | bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification | chordin | 0.673 |
BMP3 | TGFB1 | ENSP00000282701 | ENSP00000221930 | bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.652 |
BMP4 | BMP2 | ENSP00000245451 | ENSP00000368104 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.903 |
BMP4 | BMP5 | ENSP00000245451 | ENSP00000359866 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 5; Induces cartilage and bone formation | 0.969 |
BMP4 | BMP6 | ENSP00000245451 | ENSP00000283147 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.709 |
BMP4 | BMP7 | ENSP00000245451 | ENSP00000379204 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.969 |
BMP4 | CHRD | ENSP00000245451 | ENSP00000204604 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | chordin | 0.999 |
BMP4 | SFRP2 | ENSP00000245451 | ENSP00000274063 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis | 0.466 |
BMP4 | TLL2 | ENSP00000245451 | ENSP00000350630 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | tolloid-like 2; Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.787 |
BMP5 | BMP2 | ENSP00000359866 | ENSP00000368104 | bone morphogenetic protein 5; Induces cartilage and bone formation | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.969 |
BMP5 | BMP4 | ENSP00000359866 | ENSP00000245451 | bone morphogenetic protein 5; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.969 |