node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AES | UBC | ENSP00000221561 | ENSP00000344818 | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | ubiquitin C | 0.942 |
C1orf109 | CSNK2A1 | ENSP00000350704 | ENSP00000217244 | chromosome 1 open reading frame 109 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.576 |
C1orf109 | UBC | ENSP00000350704 | ENSP00000344818 | chromosome 1 open reading frame 109 | ubiquitin C | 0.483 |
C1orf109 | ZNF398 | ENSP00000350704 | ENSP00000420418 | chromosome 1 open reading frame 109 | zinc finger protein 398; Function as a transcriptional activator | 0.696 |
CSNK2A1 | C1orf109 | ENSP00000217244 | ENSP00000350704 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | chromosome 1 open reading frame 109 | 0.576 |
CSNK2A1 | STX11 | ENSP00000217244 | ENSP00000356540 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | syntaxin 11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network | 0.517 |
CSNK2A1 | UBC | ENSP00000217244 | ENSP00000344818 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | ubiquitin C | 0.973 |
IKZF3 | UBC | ENSP00000344544 | ENSP00000344818 | IKAROS family zinc finger 3 (Aiolos) | ubiquitin C | 0.816 |
KATNAL1 | UBC | ENSP00000369989 | ENSP00000344818 | katanin p60 subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity) | ubiquitin C | 0.483 |
KRT19 | UBC | ENSP00000355124 | ENSP00000344818 | keratin 19 | ubiquitin C | 0.745 |
PDE4DIP | PLK4 | ENSP00000358363 | ENSP00000270861 | phosphodiesterase 4D interacting protein | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | 0.628 |
PLK4 | PDE4DIP | ENSP00000270861 | ENSP00000358363 | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | phosphodiesterase 4D interacting protein | 0.628 |
PLK4 | UBC | ENSP00000270861 | ENSP00000344818 | polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] | ubiquitin C | 0.438 |
RNF41 | UBC | ENSP00000342755 | ENSP00000344818 | ring finger protein 41; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By s [...] | ubiquitin C | 0.977 |
SDCBP | UBC | ENSP00000260130 | ENSP00000344818 | syndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway | ubiquitin C | 0.969 |
STX11 | CSNK2A1 | ENSP00000356540 | ENSP00000217244 | syntaxin 11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.517 |
UBC | AES | ENSP00000344818 | ENSP00000221561 | ubiquitin C | amino-terminal enhancer of split; Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state | 0.942 |
UBC | C1orf109 | ENSP00000344818 | ENSP00000350704 | ubiquitin C | chromosome 1 open reading frame 109 | 0.483 |
UBC | CSNK2A1 | ENSP00000344818 | ENSP00000217244 | ubiquitin C | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.973 |
UBC | IKZF3 | ENSP00000344818 | ENSP00000344544 | ubiquitin C | IKAROS family zinc finger 3 (Aiolos) | 0.816 |