Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
||||
 | GLI1 | GLI family zinc finger 1; Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation (1106 aa) | ||
 | UBTF | upstream binding transcription factor, RNA polymerase I; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (764 aa) | ||
 | ZNF490 | zinc finger protein 490; May be involved in transcriptional regulation (529 aa) | ||
 | ZNF483 | zinc finger protein 483; May be involved in transcriptional regulation (744 aa) | ||
 | ZNF677 | zinc finger protein 677; May be involved in transcriptional regulation (584 aa) | ||
 | ZNF512 | zinc finger protein 512; May be involved in transcriptional regulation (567 aa) | ||
 | VN1R2 | vomeronasal 1 receptor 2; Putative pheromone receptor (395 aa) | ||
 | ZNF567 | zinc finger protein 567; May be involved in transcriptional regulation (616 aa) | ||
 | ZBTB37 | zinc finger and BTB domain containing 37; May be involved in transcriptional regulation (503 aa) | ||
 | MTF1 | metal-regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE) (753 aa) | ||
 | ZNF143 | zinc finger protein 143; Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (638 aa) | ||
 | ZNF461 | zinc finger protein 461; May be involved in transcriptional regulation (563 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
