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SPG21 | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation (308 aa) | |||
N4BP1 | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) (896 aa) | |||
RAB2A | RAB2A, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (212 aa) | |||
PPAT | phosphoribosyl pyrophosphate amidotransferase (517 aa) | |||
TARS | threonyl-tRNA synthetase (723 aa) | |||
SEC24D | SEC24 family, member D (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (1032 aa) | |||
HSPA4 | heat shock 70kDa protein 4 (840 aa) | |||
TLN1 | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) (2541 aa) | |||
TENC1 | tensin like C1 domain containing phosphatase (tensin 2) (1419 aa) | |||
RSU1 | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro (277 aa) | |||
THUMPD3 | THUMP domain containing 3 (507 aa) | |||
AKT1S1 | AKT1 substrate 1 (proline-rich); Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesi [...] (256 aa) | |||
FAM114A1 | family with sequence similarity 114, member A1; May play a role in neuronal cell development (By similarity) (563 aa) | |||
FAF1 | Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis (650 aa) | |||
RAB2B | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) (216 aa) |