node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NEDD4 | SMAD2 | ENSP00000345530 | ENSP00000262160 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | 0.775 |
NEDD4 | SMAD3 | ENSP00000345530 | ENSP00000332973 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | SMAD family member 3 | 0.872 |
NEDD4 | UBC | ENSP00000345530 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
NEDD4L | SMAD2 | ENSP00000383199 | ENSP00000262160 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | 0.980 |
NEDD4L | SMAD3 | ENSP00000383199 | ENSP00000332973 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | SMAD family member 3 | 0.994 |
NEDD4L | SMURF1 | ENSP00000383199 | ENSP00000354621 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA | 0.908 |
NEDD4L | UBC | ENSP00000383199 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
SMAD2 | NEDD4 | ENSP00000262160 | ENSP00000345530 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.775 |
SMAD2 | NEDD4L | ENSP00000262160 | ENSP00000383199 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.980 |
SMAD2 | SMAD3 | ENSP00000262160 | ENSP00000332973 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | SMAD family member 3 | 0.999 |
SMAD2 | SMURF1 | ENSP00000262160 | ENSP00000354621 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA | 0.998 |
SMAD2 | SMURF2 | ENSP00000262160 | ENSP00000262435 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | SMAD specific E3 ubiquitin protein ligase 2 | 0.965 |
SMAD2 | UBC | ENSP00000262160 | ENSP00000344818 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | ubiquitin C | 0.999 |
SMAD3 | NEDD4 | ENSP00000332973 | ENSP00000345530 | SMAD family member 3 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.872 |
SMAD3 | NEDD4L | ENSP00000332973 | ENSP00000383199 | SMAD family member 3 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.994 |
SMAD3 | SMAD2 | ENSP00000332973 | ENSP00000262160 | SMAD family member 3 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | 0.999 |
SMAD3 | SMURF1 | ENSP00000332973 | ENSP00000354621 | SMAD family member 3 | SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA | 0.997 |
SMAD3 | SMURF2 | ENSP00000332973 | ENSP00000262435 | SMAD family member 3 | SMAD specific E3 ubiquitin protein ligase 2 | 0.954 |
SMAD3 | UBC | ENSP00000332973 | ENSP00000344818 | SMAD family member 3 | ubiquitin C | 0.999 |
SMURF1 | NEDD4L | ENSP00000354621 | ENSP00000383199 | SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.908 |