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CD38 CD38 CALM3 CALM3 SCGN SCGN CALM2 CALM2 CABP5 CABP5 CALM1 CALM1 RYR1 RYR1 CABP1 CABP1 ASPH ASPH CABP2 CABP2 OCM OCM NOS1 NOS1 CABP4 CABP4 OCM2 OCM2 EFCAB3 EFCAB3 UNG UNG CALML4 CALML4 EFCAB6 EFCAB6 CALN1 CALN1 PVALB PVALB CALB2 CALB2 RHBDL3 RHBDL3 EFCAB13 EFCAB13 EFCAB9 EFCAB9 SPATA21 SPATA21 CALB1 CALB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PVALBparvalbumin; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (110 aa)
CD38CD38 molecule; Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system (300 aa)
OCMoncomodulin; Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions (109 aa)
UNGuracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) (313 aa)
OCM2oncomodulin 2 (109 aa)
EFCAB6EF-hand calcium binding domain 6 (1501 aa)
CALB1calbindin 1, 28kDa; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3’,5’-cyclic nucleotide phosphodiesterase (261 aa)
RHBDL3rhomboid, veinlet-like 3 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) (404 aa)
CALM2calmodulin 2 (phosphorylase kinase, delta) (149 aa)
CALM3calmodulin 3 (phosphorylase kinase, delta) (149 aa)
CABP5calcium binding protein 5; Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the transmission of light signals (By similarity) (173 aa)
CABP2calcium binding protein 2 (220 aa)
CALB2calbindin 2; Calretinin is a calcium-binding protein which is abundant in auditory neurons (271 aa)
CABP1calcium binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similari [...] (370 aa)
CABP4calcium binding protein 4; Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity) (275 aa)
EFCAB13EF-hand calcium binding domain 13 (973 aa)
SPATA21spermatogenesis associated 21; Involved in the differentiation of haploid spermatids (By similarity) (469 aa)
NOS1nitric oxide synthase 1 (neuronal); Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (1468 aa)
CALM1calmodulin 1 (phosphorylase kinase, delta) (149 aa)
RYR1ryanodine receptor 1 (skeletal); Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Requi [...] (5038 aa)
SCGNsecretagogin, EF-hand calcium binding protein (276 aa)
ASPHaspartate beta-hydroxylase (758 aa)
CALN1calneuron 1; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning (261 aa)
EFCAB9EF-hand calcium binding domain 9 (197 aa)
EFCAB3EF-hand calcium binding domain 3 (490 aa)
CALML4calmodulin-like 4 (196 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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