node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG2A | ATG2B | ENSP00000366475 | ENSP00000353010 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.621 |
ATG2A | ATG9A | ENSP00000366475 | ENSP00000355173 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 9A | 0.976 |
ATG2A | WDR45 | ENSP00000366475 | ENSP00000348848 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain 45 | 0.790 |
ATG2A | WIPI1 | ENSP00000366475 | ENSP00000262139 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] | 0.997 |
ATG2A | WIPI2 | ENSP00000366475 | ENSP00000288828 | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.988 |
ATG2B | ATG2A | ENSP00000353010 | ENSP00000366475 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.621 |
ATG2B | ATG9A | ENSP00000353010 | ENSP00000355173 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | autophagy related 9A | 0.969 |
ATG2B | WDR45 | ENSP00000353010 | ENSP00000348848 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain 45 | 0.999 |
ATG2B | WIPI1 | ENSP00000353010 | ENSP00000262139 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] | 0.986 |
ATG2B | WIPI2 | ENSP00000353010 | ENSP00000288828 | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.985 |
ATG9A | ATG2A | ENSP00000355173 | ENSP00000366475 | autophagy related 9A | autophagy related 2A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.976 |
ATG9A | ATG2B | ENSP00000355173 | ENSP00000353010 | autophagy related 9A | autophagy related 2B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion | 0.969 |
ATG9A | WDR45 | ENSP00000355173 | ENSP00000348848 | autophagy related 9A | WD repeat domain 45 | 0.673 |
ATG9A | WIPI1 | ENSP00000355173 | ENSP00000262139 | autophagy related 9A | WD repeat domain, phosphoinositide interacting 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is dist [...] | 0.943 |
ATG9A | WIPI2 | ENSP00000355173 | ENSP00000288828 | autophagy related 9A | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.936 |
DNM1 | DNM2 | ENSP00000362014 | ENSP00000347890 | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | 0.917 |
DNM1 | MX1 | ENSP00000362014 | ENSP00000381599 | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 0.905 |
DNM2 | DNM1 | ENSP00000347890 | ENSP00000362014 | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | 0.917 |
DNM2 | WIPI2 | ENSP00000347890 | ENSP00000288828 | dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.482 |
MX1 | DNM1 | ENSP00000381599 | ENSP00000362014 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | dynamin 1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis | 0.905 |