node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | ACTN2 | ENSP00000349960 | ENSP00000355537 | actin, beta | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.994 |
ACTB | FLNC | ENSP00000349960 | ENSP00000327145 | actin, beta | filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers | 0.427 |
ACTB | NRAP | ENSP00000349960 | ENSP00000353078 | actin, beta | nebulin-related anchoring protein | 0.615 |
ACTB | TLN1 | ENSP00000349960 | ENSP00000316029 | actin, beta | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | 0.645 |
ACTB | VCL | ENSP00000349960 | ENSP00000211998 | actin, beta | vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion | 0.872 |
ACTN2 | ACTB | ENSP00000355537 | ENSP00000349960 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | actin, beta | 0.994 |
ACTN2 | NRAP | ENSP00000355537 | ENSP00000353078 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | nebulin-related anchoring protein | 0.684 |
ACTN2 | TLN1 | ENSP00000355537 | ENSP00000316029 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | 0.941 |
ACTN2 | VCL | ENSP00000355537 | ENSP00000211998 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion | 0.988 |
FLNC | ACTB | ENSP00000327145 | ENSP00000349960 | filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers | actin, beta | 0.427 |
FLNC | TLN1 | ENSP00000327145 | ENSP00000316029 | filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | 0.511 |
FLNC | VCL | ENSP00000327145 | ENSP00000211998 | filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers | vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion | 0.596 |
KBTBD10 | NRAP | ENSP00000284669 | ENSP00000353078 | kelch repeat and BTB (POZ) domain containing 10; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells (By similarity) | nebulin-related anchoring protein | 0.725 |
NRAP | ACTB | ENSP00000353078 | ENSP00000349960 | nebulin-related anchoring protein | actin, beta | 0.615 |
NRAP | ACTN2 | ENSP00000353078 | ENSP00000355537 | nebulin-related anchoring protein | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.684 |
NRAP | KBTBD10 | ENSP00000353078 | ENSP00000284669 | nebulin-related anchoring protein | kelch repeat and BTB (POZ) domain containing 10; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells (By similarity) | 0.725 |
NRAP | TLN1 | ENSP00000353078 | ENSP00000316029 | nebulin-related anchoring protein | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | 0.593 |
NRAP | VCL | ENSP00000353078 | ENSP00000211998 | nebulin-related anchoring protein | vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion | 0.593 |
TLN1 | ACTB | ENSP00000316029 | ENSP00000349960 | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | actin, beta | 0.645 |
TLN1 | ACTN2 | ENSP00000316029 | ENSP00000355537 | talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.941 |