Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
TJP2 TJP2 DEF8 DEF8 TJP1 TJP1 FHL3 FHL3 DLL1 DLL1 NPHS1 NPHS1 DMWD DMWD PSMA3 PSMA3 KIRREL3 KIRREL3 KIRREL2 KIRREL2 WDR20 WDR20 TANC1 TANC1 TANC2 TANC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PSMA3proteasome (prosome, macropain) subunit, alpha type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2 (255 aa)
TANC1tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1; May be a scaffold component in the postsynaptic density (By similarity) (1861 aa)
DEF8differentially expressed in FDCP 8 homolog (mouse) (512 aa)
DMWDdystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis (674 aa)
TJP1tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (1748 aa)
KIRREL2kin of IRRE like 2 (Drosophila) (708 aa)
DLL1delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (723 aa)
FHL3four and a half LIM domains 3 (280 aa)
NPHS1nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) (1241 aa)
TANC2tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (1990 aa)
WDR20WD repeat domain 20 (600 aa)
KIRREL3kin of IRRE like 3 (Drosophila); Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity) (778 aa)
TJP2tight junction protein 2 (1221 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (57%)