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KEAP1 | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (624 aa) | |||
CBFA2T3 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (653 aa) | |||
GYPA | glycophorin A (MNS blood group); Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to [...] (150 aa) | |||
RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (615 aa) | |||
GYPB | glycophorin B (MNS blood group); This protein is a minor sialoglycoprotein in erythrocyte membranes (91 aa) |