node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL22RA2 | SIGLEC14 | ENSP00000296980 | ENSP00000354090 | interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | 0.576 |
IL22RA2 | SIRPA | ENSP00000296980 | ENSP00000348307 | interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses | signal-regulatory protein alpha | 0.576 |
MDGA2 | SIGLEC14 | ENSP00000382178 | ENSP00000354090 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | 0.963 |
SIGLEC11 | SIGLEC14 | ENSP00000412361 | ENSP00000354090 | sialic acid binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | 0.907 |
SIGLEC11 | SIGLEC15 | ENSP00000412361 | ENSP00000374125 | sialic acid binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules | sialic acid binding Ig-like lectin 15; Binds sialylated glycoproteins | 0.908 |
SIGLEC11 | TYROBP | ENSP00000412361 | ENSP00000262629 | sialic acid binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules | TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.943 |
SIGLEC14 | IL22RA2 | ENSP00000354090 | ENSP00000296980 | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses | 0.576 |
SIGLEC14 | MDGA2 | ENSP00000354090 | ENSP00000382178 | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | 0.963 |
SIGLEC14 | SIGLEC11 | ENSP00000354090 | ENSP00000412361 | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | sialic acid binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules | 0.907 |
SIGLEC14 | SIGLEC15 | ENSP00000354090 | ENSP00000374125 | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | sialic acid binding Ig-like lectin 15; Binds sialylated glycoproteins | 0.903 |
SIGLEC14 | SIRPA | ENSP00000354090 | ENSP00000348307 | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | signal-regulatory protein alpha | 0.576 |
SIGLEC14 | TYROBP | ENSP00000354090 | ENSP00000262629 | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.977 |
SIGLEC15 | SIGLEC11 | ENSP00000374125 | ENSP00000412361 | sialic acid binding Ig-like lectin 15; Binds sialylated glycoproteins | sialic acid binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules | 0.908 |
SIGLEC15 | SIGLEC14 | ENSP00000374125 | ENSP00000354090 | sialic acid binding Ig-like lectin 15; Binds sialylated glycoproteins | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | 0.903 |
SIGLEC15 | SIGLEC7 | ENSP00000374125 | ENSP00000323328 | sialic acid binding Ig-like lectin 15; Binds sialylated glycoproteins | sialic acid binding Ig-like lectin 7; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their [...] | 0.445 |
SIGLEC15 | TYROBP | ENSP00000374125 | ENSP00000262629 | sialic acid binding Ig-like lectin 15; Binds sialylated glycoproteins | TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.912 |
SIGLEC7 | SIGLEC15 | ENSP00000323328 | ENSP00000374125 | sialic acid binding Ig-like lectin 7; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their [...] | sialic acid binding Ig-like lectin 15; Binds sialylated glycoproteins | 0.445 |
SIRPA | IL22RA2 | ENSP00000348307 | ENSP00000296980 | signal-regulatory protein alpha | interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses | 0.576 |
SIRPA | SIGLEC14 | ENSP00000348307 | ENSP00000354090 | signal-regulatory protein alpha | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | 0.576 |
SIRPA | TYROBP | ENSP00000348307 | ENSP00000262629 | signal-regulatory protein alpha | TYRO protein tyrosine kinase binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin | 0.864 |