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HDGF HDGF LEO1 LEO1 CTRB1 CTRB1 F2RL1 F2RL1 NGF NGF SHC1 SHC1 UBC UBC F2RL2 F2RL2 APP APP SERPINA1 SERPINA1 F2RL3 F2RL3 F2R F2R ALB ALB PARD3 PARD3 PRSS3 PRSS3 GIF GIF CTRL CTRL TCN1 TCN1 TFPI TFPI DEFA5 DEFA5 CTRB2 CTRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (304 aa)
F2RL3coagulation factor II (thrombin) receptor-like 3; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation (385 aa)
GIFgastric intrinsic factor (vitamin B synthesis); Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis (417 aa)
TCN1transcobalamin I (vitamin B12 binding protein, R binder family); Vitamin B12-binding protein. Transports cobalamin into cells (433 aa)
APPamyloid beta (A4) precursor protein (770 aa)
ALBalbumin (609 aa)
F2RL2coagulation factor II (thrombin) receptor-like 2; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis (374 aa)
F2RL1coagulation factor II (thrombin) receptor-like 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I- kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can sig [...] (397 aa)
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and ’Ser-2’- and ’Ser-5’-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is r [...] (666 aa)
CTRB2chymotrypsinogen B2 (263 aa)
F2Rcoagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development (425 aa)
DEFA5defensin, alpha 5, Paneth cell-specific; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (94 aa)
UBCubiquitin C (685 aa)
SERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (418 aa)
PRSS3protease, serine, 3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5 (304 aa)
CTRB1chymotrypsinogen B1 (263 aa)
HDGFhepatoma-derived growth factor; Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (256 aa)
NGFnerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival (241 aa)
PARD3par-3 partitioning defective 3 homolog (C. elegans) (1356 aa)
SHC1SHC (Src homology 2 domain containing) transforming protein 1 (584 aa)
CTRLchymotrypsin-like (264 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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