node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BABAM1 | MICU1 | ENSP00000352408 | ENSP00000354415 | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | mitochondrial calcium uptake 1 | 0.740 |
BABAM1 | UBC | ENSP00000352408 | ENSP00000344818 | BRISC and BRCA1 A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes ’Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ’Lys-63’-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprote [...] | ubiquitin C | 0.948 |
C22orf32 | CCDC109B | ENSP00000327467 | ENSP00000378145 | chromosome 22 open reading frame 32 | coiled-coil domain containing 109B | 0.959 |
C22orf32 | EFHA1 | ENSP00000327467 | ENSP00000371811 | chromosome 22 open reading frame 32 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.939 |
C22orf32 | MCU | ENSP00000327467 | ENSP00000362144 | chromosome 22 open reading frame 32 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.936 |
C22orf32 | MICU1 | ENSP00000327467 | ENSP00000354415 | chromosome 22 open reading frame 32 | mitochondrial calcium uptake 1 | 0.958 |
CCDC109B | C22orf32 | ENSP00000378145 | ENSP00000327467 | coiled-coil domain containing 109B | chromosome 22 open reading frame 32 | 0.959 |
CCDC109B | EFHA1 | ENSP00000378145 | ENSP00000371811 | coiled-coil domain containing 109B | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.938 |
CCDC109B | MCU | ENSP00000378145 | ENSP00000362144 | coiled-coil domain containing 109B | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.911 |
CCDC109B | MICU1 | ENSP00000378145 | ENSP00000354415 | coiled-coil domain containing 109B | mitochondrial calcium uptake 1 | 0.949 |
EFHA1 | C22orf32 | ENSP00000371811 | ENSP00000327467 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | chromosome 22 open reading frame 32 | 0.939 |
EFHA1 | CCDC109B | ENSP00000371811 | ENSP00000378145 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | coiled-coil domain containing 109B | 0.938 |
EFHA1 | MCU | ENSP00000371811 | ENSP00000362144 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.973 |
EFHA1 | MICU1 | ENSP00000371811 | ENSP00000354415 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | mitochondrial calcium uptake 1 | 0.923 |
EFHA1 | UBC | ENSP00000371811 | ENSP00000344818 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | ubiquitin C | 0.721 |
MCU | C22orf32 | ENSP00000362144 | ENSP00000327467 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | chromosome 22 open reading frame 32 | 0.936 |
MCU | CCDC109B | ENSP00000362144 | ENSP00000378145 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | coiled-coil domain containing 109B | 0.911 |
MCU | EFHA1 | ENSP00000362144 | ENSP00000371811 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.973 |
MCU | MICU1 | ENSP00000362144 | ENSP00000354415 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | mitochondrial calcium uptake 1 | 0.998 |
MCU | UBC | ENSP00000362144 | ENSP00000344818 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | ubiquitin C | 0.655 |