node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BHLHB9 | IPO5 | ENSP00000354675 | ENSP00000261574 | basic helix-loop-helix domain containing, class B, 9; May play a role in the control of cellular aging and survival | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.622 |
BHLHB9 | PPP2R4 | ENSP00000354675 | ENSP00000351885 | basic helix-loop-helix domain containing, class B, 9; May play a role in the control of cellular aging and survival | protein phosphatase 2A activator, regulatory subunit 4 | 0.587 |
BHLHB9 | PPP2R5E | ENSP00000354675 | ENSP00000337641 | basic helix-loop-helix domain containing, class B, 9; May play a role in the control of cellular aging and survival | protein phosphatase 2, regulatory subunit B’, epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.576 |
BHLHB9 | UBC | ENSP00000354675 | ENSP00000344818 | basic helix-loop-helix domain containing, class B, 9; May play a role in the control of cellular aging and survival | ubiquitin C | 0.620 |
IPO5 | BHLHB9 | ENSP00000261574 | ENSP00000354675 | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | basic helix-loop-helix domain containing, class B, 9; May play a role in the control of cellular aging and survival | 0.622 |
IPO5 | UBC | ENSP00000261574 | ENSP00000344818 | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | ubiquitin C | 0.975 |
PPP2R4 | BHLHB9 | ENSP00000351885 | ENSP00000354675 | protein phosphatase 2A activator, regulatory subunit 4 | basic helix-loop-helix domain containing, class B, 9; May play a role in the control of cellular aging and survival | 0.587 |
PPP2R4 | PPP2R5E | ENSP00000351885 | ENSP00000337641 | protein phosphatase 2A activator, regulatory subunit 4 | protein phosphatase 2, regulatory subunit B’, epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.858 |
PPP2R4 | UBC | ENSP00000351885 | ENSP00000344818 | protein phosphatase 2A activator, regulatory subunit 4 | ubiquitin C | 0.872 |
PPP2R5E | BHLHB9 | ENSP00000337641 | ENSP00000354675 | protein phosphatase 2, regulatory subunit B’, epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | basic helix-loop-helix domain containing, class B, 9; May play a role in the control of cellular aging and survival | 0.576 |
PPP2R5E | PPP2R4 | ENSP00000337641 | ENSP00000351885 | protein phosphatase 2, regulatory subunit B’, epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | protein phosphatase 2A activator, regulatory subunit 4 | 0.858 |
PPP2R5E | UBC | ENSP00000337641 | ENSP00000344818 | protein phosphatase 2, regulatory subunit B’, epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | ubiquitin C | 0.814 |
UBC | BHLHB9 | ENSP00000344818 | ENSP00000354675 | ubiquitin C | basic helix-loop-helix domain containing, class B, 9; May play a role in the control of cellular aging and survival | 0.620 |
UBC | IPO5 | ENSP00000344818 | ENSP00000261574 | ubiquitin C | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.975 |
UBC | PPP2R4 | ENSP00000344818 | ENSP00000351885 | ubiquitin C | protein phosphatase 2A activator, regulatory subunit 4 | 0.872 |
UBC | PPP2R5E | ENSP00000344818 | ENSP00000337641 | ubiquitin C | protein phosphatase 2, regulatory subunit B’, epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.814 |