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STRINGSTRING
SLC30A2 SLC30A2 SLC39A13 SLC39A13 SLC30A4 SLC30A4 SLC30A3 SLC30A3 SLC39A1 SLC39A1 SLC39A3 SLC39A3 SLC30A5 SLC30A5 SLC39A2 SLC39A2 SLC30A8 SLC30A8 SLC30A1 SLC30A1 SLC30A7 SLC30A7 SLC30A6 SLC30A6 SLC30A10 SLC30A10 REL REL TCF4 TCF4 ENSG00000267001 ENSG00000267001
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SLC30A3solute carrier family 30 (zinc transporter), member 3; Involved in accumulation of zinc in synaptic vesicles (By similarity) (388 aa)
SLC30A4solute carrier family 30 (zinc transporter), member 4; Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment (429 aa)
SLC39A3solute carrier family 39 (zinc transporter), member 3; Acts as a zinc-influx transporter (Potential) (314 aa)
RELv-rel reticuloendotheliosis viral oncogene homolog (avian); Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the i [...] (619 aa)
SLC39A2solute carrier family 39 (zinc transporter), member 2; Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis (309 aa)
SLC39A1solute carrier family 39 (zinc transporter), member 1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells (324 aa)
TCF4transcription factor 4 (671 aa)
SLC30A7solute carrier family 30 (zinc transporter), member 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity) (376 aa)
SLC39A13solute carrier family 39 (zinc transporter), member 13; Acts as a zinc-influx transporter (371 aa)
SLC30A10solute carrier family 30, member 10; May be involved in zinc transport out of the cell, being a zinc-efflux transporter (By similarity) (485 aa)
SLC30A1solute carrier family 30 (zinc transporter), member 1; May be involved in zinc transport out of the cell (507 aa)
SLC30A2solute carrier family 30 (zinc transporter), member 2 (372 aa)
SLC30A6solute carrier family 30 (zinc transporter), member 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment (By similarity) (501 aa)
SLC30A5solute carrier family 30 (zinc transporter), member 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (765 aa)
SLC30A8solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells (369 aa)
ENSG00000267001Uncharacterized protein (105 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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