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RPS28 RPS28 EIF1B EIF1B RPS2 RPS2 RPS16 RPS16 RPS7 RPS7 RPS8 RPS8 RPS23 RPS23 RPS15A RPS15A RPS14 RPS14 RPS29 RPS29 UBC UBC FAU FAU EIF1AY EIF1AY RPS3 RPS3 EIF5 EIF5 RPS27A RPS27A RPS20 RPS20 EIF2S2 EIF2S2 EIF5B EIF5B RPS15 RPS15 RPS13 RPS13 RPS24 RPS24 RPS19 RPS19 RPS11 RPS11 RPS6 RPS6 EIF1 EIF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
EIF5eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (431 aa)
EIF1Beukaryotic translation initiation factor 1B; Probably involved in translation (113 aa)
RPS16ribosomal protein S16 (146 aa)
RPS11ribosomal protein S11 (158 aa)
RPS27Aribosomal protein S27a (156 aa)
EIF5Beukaryotic translation initiation factor 5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity) (1220 aa)
RPS23ribosomal protein S23 (143 aa)
RPS14ribosomal protein S14 (151 aa)
RPS15Aribosomal protein S15a (130 aa)
RPS7ribosomal protein S7; Required for rRNA maturation (194 aa)
RPS2ribosomal protein S2 (293 aa)
UBCubiquitin C (685 aa)
EIF1AYeukaryotic translation initiation factor 1A, Y-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity) (144 aa)
EIF2S2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a rea [...] (333 aa)
RPS6ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (249 aa)
RPS29ribosomal protein S29 (67 aa)
RPS8ribosomal protein S8 (208 aa)
RPS24ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits (289 aa)
EIF1eukaryotic translation initiation factor 1; Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (113 aa)
RPS20ribosomal protein S20 (142 aa)
FAUFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa)
RPS3ribosomal protein S3 (243 aa)
RPS13ribosomal protein S13 (151 aa)
RPS15ribosomal protein S15 (145 aa)
RPS19ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits (145 aa)
RPS28ribosomal protein S28 (69 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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