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STRINGSTRING
NOTCH2 NOTCH2 BCL3 BCL3 DLL1 DLL1 NOTCH4 NOTCH4 CUX1 CUX1 ANKRD1 ANKRD1 SBNO2 SBNO2 VGLL2 VGLL2 UBC UBC NOTCH3 NOTCH3 NOTCH1 NOTCH1 POTEI POTEI EYS EYS CUX2 CUX2 ONECUT2 ONECUT2 ONECUT1 ONECUT1 SNED1 SNED1 ONECUT3 ONECUT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
BCL3B-cell CLL/lymphoma 3; Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity) (454 aa)
NOTCH2notch 2 (2471 aa)
CUX2cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) (1486 aa)
ONECUT2one cut homeobox 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B (504 aa)
NOTCH3notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) (2321 aa)
NOTCH1notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] (2555 aa)
ONECUT1one cut homeobox 1; Transcriptional activator. Binds the consensus sequence 5’-DHWATTGAYTWWD-3’ on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription (465 aa)
SNED1sushi, nidogen and EGF-like domains 1 (1413 aa)
VGLL2vestigial like 2 (Drosophila); May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles (317 aa)
UBCubiquitin C (685 aa)
CUX1cut-like homeobox 1; May be involved in intra-Golgi retrograde transport (1516 aa)
SBNO2strawberry notch homolog 2 (Drosophila); Seems to have transcriptional repression activity in macrophages (1366 aa)
DLL1delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (723 aa)
ANKRD1ankyrin repeat domain 1 (cardiac muscle); May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells (319 aa)
NOTCH4notch 4 (2003 aa)
ONECUT3one cut homeobox 3; Transcriptional activator. Binds the consensus DNA sequence 5’-DHWATTGAYTWWD-3’ on a variety of gene promoters such as those of HNF3B and TTR (By similarity) (494 aa)
POTEIPOTE ankyrin domain family, member I (1075 aa)
EYSeyes shut homolog (Drosophila) (3144 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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