node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR2 | ACTR3 | ENSP00000367220 | ENSP00000263238 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | 0.999 |
ACTR2 | ANP32B | ENSP00000367220 | ENSP00000345848 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome | 0.577 |
ACTR2 | EFTUD1 | ENSP00000367220 | ENSP00000268206 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | elongation factor Tu GTP binding domain containing 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits | 0.529 |
ACTR2 | KIAA1279 | ENSP00000367220 | ENSP00000354848 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | KIAA1279; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Regulates mitochondrial transport by modulating KIF1B motor activity | 0.511 |
ACTR2 | OSGEP | ENSP00000367220 | ENSP00000206542 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | 0.410 |
ACTR2 | PANK4 | ENSP00000367220 | ENSP00000367727 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | pantothenate kinase 4; Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity) | 0.418 |
ACTR2 | PRKACB | ENSP00000367220 | ENSP00000359719 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | protein kinase, cAMP-dependent, catalytic, beta | 0.457 |
ACTR2 | RANGAP1 | ENSP00000367220 | ENSP00000348577 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | Ran GTPase activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state | 0.477 |
ACTR2 | TP53RK | ENSP00000367220 | ENSP00000361186 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | TP53 regulating kinase; Protein kinase that phosphorylates ’Ser-15’ of p53/TP53 protein and may therefore participate in its activation | 0.480 |
ACTR2 | UBC | ENSP00000367220 | ENSP00000344818 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | ubiquitin C | 0.995 |
ACTR2 | UFM1 | ENSP00000367220 | ENSP00000239878 | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1 | 0.403 |
ACTR3 | ACTR2 | ENSP00000263238 | ENSP00000367220 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament | 0.999 |
ACTR3 | ANP32B | ENSP00000263238 | ENSP00000345848 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome | 0.529 |
ACTR3 | KIAA1279 | ENSP00000263238 | ENSP00000354848 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | KIAA1279; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. Regulates mitochondrial transport by modulating KIF1B motor activity | 0.509 |
ACTR3 | PRKACB | ENSP00000263238 | ENSP00000359719 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | protein kinase, cAMP-dependent, catalytic, beta | 0.549 |
ACTR3 | RANGAP1 | ENSP00000263238 | ENSP00000348577 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | Ran GTPase activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state | 0.406 |
ACTR3 | SH3GL1 | ENSP00000263238 | ENSP00000269886 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) | 0.592 |
ACTR3 | TP53RK | ENSP00000263238 | ENSP00000361186 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | TP53 regulating kinase; Protein kinase that phosphorylates ’Ser-15’ of p53/TP53 protein and may therefore participate in its activation | 0.479 |
ACTR3 | TPRKB | ENSP00000263238 | ENSP00000272424 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | TP53RK binding protein | 0.490 |
ACTR3 | UBC | ENSP00000263238 | ENSP00000344818 | ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis | ubiquitin C | 0.961 |