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STRINGSTRING
COL6A2 COL6A2 COL22A1 COL22A1 COL19A1 COL19A1 COL9A1 COL9A1 COL5A2 COL5A2 COL6A3 COL6A3 COL6A5 COL6A5 COL14A1 COL14A1 COL1A1 COL1A1 COL27A1 COL27A1 COL12A1 COL12A1 COL17A1 COL17A1 COL9A2 COL9A2 COL11A1 COL11A1 COL5A1 COL5A1 COL21A1 COL21A1 COL9A3 COL9A3 PLOD3 PLOD3 COL8A1 COL8A1 COL4A1 COL4A1 COL23A1 COL23A1 GLT25D2 GLT25D2 COL10A1 COL10A1 COL18A1 COL18A1 COL4A4 COL4A4 PLOD1 PLOD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PLOD1procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (727 aa)
PLOD3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (738 aa)
COL1A1collagen, type I, alpha 1 (1464 aa)
COL10A1collagen, type X, alpha 1; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage (680 aa)
COL21A1collagen, type XXI, alpha 1 (957 aa)
COL8A1collagen, type VIII, alpha 1; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (744 aa)
COL6A5collagen, type VI, alpha 5 (2615 aa)
COL6A3collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein (3177 aa)
COL14A1collagen, type XIV, alpha 1 (1796 aa)
COL6A2collagen, type VI, alpha 2 (1019 aa)
COL22A1collagen, type XXII, alpha 1; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts (1626 aa)
COL19A1collagen, type XIX, alpha 1 (1142 aa)
COL12A1collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) (3063 aa)
COL17A1collagen, type XVII, alpha 1; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane (1497 aa)
COL9A3collagen, type IX, alpha 3; Structural component of hyaline cartilage and vitreous of the eye (684 aa)
COL18A1collagen, type XVIII, alpha 1 (1519 aa)
COL27A1collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)
COL9A1collagen, type IX, alpha 1 (921 aa)
GLT25D2glycosyltransferase 25 domain containing 2; Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues on collagen (626 aa)
COL11A1collagen, type XI, alpha 1 (1806 aa)
COL5A1collagen, type V, alpha 1; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (1838 aa)
COL9A2collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye (689 aa)
COL5A2collagen, type V, alpha 2 (1499 aa)
COL4A1collagen, type IV, alpha 1; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1669 aa)
COL23A1collagen, type XXIII, alpha 1 (540 aa)
COL4A4collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1690 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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