Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ILK | PPP1R14C | ENSP00000299421 | ENSP00000355260 | integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B | protein phosphatase 1, regulatory (inhibitor) subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | 0.981 |
PPP1R14C | ILK | ENSP00000355260 | ENSP00000299421 | protein phosphatase 1, regulatory (inhibitor) subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B | 0.981 |
PPP1R14C | SAP25 | ENSP00000355260 | ENSP00000442339 | protein phosphatase 1, regulatory (inhibitor) subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | Sin3A-associated protein, 25kDa; Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex (By similarity) | 0.501 |
PPP1R14C | UBL7 | ENSP00000355260 | ENSP00000354883 | protein phosphatase 1, regulatory (inhibitor) subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | ubiquitin-like 7 (bone marrow stromal cell-derived) | 0.644 |
PPP1R14C | VPS35 | ENSP00000355260 | ENSP00000299138 | protein phosphatase 1, regulatory (inhibitor) subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.644 |
SAP25 | PPP1R14C | ENSP00000442339 | ENSP00000355260 | Sin3A-associated protein, 25kDa; Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex (By similarity) | protein phosphatase 1, regulatory (inhibitor) subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | 0.501 |
SIRT3 | SIRT5 | ENSP00000372191 | ENSP00000368552 | sirtuin 3; NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels | sirtuin 5; NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting- acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro | 0.808 |
SIRT5 | SIRT3 | ENSP00000368552 | ENSP00000372191 | sirtuin 5; NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting- acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro | sirtuin 3; NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels | 0.808 |
UBL7 | PPP1R14C | ENSP00000354883 | ENSP00000355260 | ubiquitin-like 7 (bone marrow stromal cell-derived) | protein phosphatase 1, regulatory (inhibitor) subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | 0.644 |
VPS35 | PPP1R14C | ENSP00000299138 | ENSP00000355260 | vacuolar protein sorting 35 homolog (S. cerevisiae) | protein phosphatase 1, regulatory (inhibitor) subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA | 0.644 |