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STRINGSTRING
RPL8 RPL8 RPS28 RPS28 RPS23 RPS23 RPL26 RPL26 UPF3B UPF3B SMG5 SMG5 SMG8 SMG8 RPL30 RPL30 RPS3A RPS3A RPL35 RPL35 PPP2CA PPP2CA RPS16 RPS16 UBA52 UBA52 RPL4 RPL4 RPL37 RPL37 RPLP2 RPLP2 SMG9 SMG9 RPL23 RPL23 RPS2 RPS2 RPS29 RPS29 RPL41 RPL41 UPF3A UPF3A RPL18 RPL18 UPF1 UPF1 RPL17 RPL17 RPS21 RPS21
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RPS16ribosomal protein S16 (146 aa)
RPL35ribosomal protein L35 (123 aa)
RPL8ribosomal protein L8 (257 aa)
UPF1UPF1 regulator of nonsense transcripts homolog (yeast); RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (loc [...] (1118 aa)
SMG9smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans); Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (520 aa)
RPL37ribosomal protein L37; Binds to the 23S rRNA (By similarity) (97 aa)
UPF3BUPF3 regulator of nonsense transcripts homolog B (yeast); Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mR [...] (483 aa)
RPL30ribosomal protein L30 (115 aa)
RPL26ribosomal protein L26 (145 aa)
RPS23ribosomal protein S23 (143 aa)
SMG8smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans); Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome-SURF complex and to suppress SMG1 kinase activity until the ribosome-SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (991 aa)
RPL4ribosomal protein L4 (427 aa)
RPLP2ribosomal protein, large, P2; Plays an important role in the elongation step of protein synthesis (115 aa)
RPS2ribosomal protein S2 (293 aa)
RPS21ribosomal protein S21 (83 aa)
RPS3Aribosomal protein S3A; May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity) (264 aa)
SMG5smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans); Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (1016 aa)
UPF3AUPF3 regulator of nonsense transcripts homolog A (yeast); Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA [...] (476 aa)
RPL23ribosomal protein L23 (140 aa)
RPS29ribosomal protein S29 (67 aa)
UBA52ubiquitin A-52 residue ribosomal protein fusion product 1 (128 aa)
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ (309 aa)
RPL41ribosomal protein L41 (25 aa)
RPL18ribosomal protein L18 (188 aa)
RPL17ribosomal protein L17 (184 aa)
RPS28ribosomal protein S28 (69 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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