node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000171570 | STX4 | ENSP00000469872 | ENSP00000317714 | RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.740 |
EPS15 | RAB4A | ENSP00000360798 | ENSP00000355651 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.530 |
IPO5 | XPO6 | ENSP00000261574 | ENSP00000302790 | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | exportin 6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells | 0.652 |
RAB4A | EPS15 | ENSP00000355651 | ENSP00000360798 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.530 |
RAB4A | SNAP23 | ENSP00000355651 | ENSP00000249647 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | 0.498 |
RAB4A | STX4 | ENSP00000355651 | ENSP00000317714 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.986 |
RAB4A | STX6 | ENSP00000355651 | ENSP00000258301 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | syntaxin 6; Involved in intracellular vesicle trafficking | 0.470 |
RAB4A | VAMP3 | ENSP00000355651 | ENSP00000054666 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | 0.746 |
RAB4B | STX4 | ENSP00000349560 | ENSP00000317714 | RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.733 |
RAB4B | VAMP3 | ENSP00000349560 | ENSP00000054666 | RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | 0.536 |
RANBP6 | XPO6 | ENSP00000259569 | ENSP00000302790 | RAN binding protein 6; May function in nuclear protein import as nuclear transport receptor | exportin 6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells | 0.624 |
SCAMP5 | SLC9A7 | ENSP00000355387 | ENSP00000330320 | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis | 0.715 |
SCAMP5 | SNAP23 | ENSP00000355387 | ENSP00000249647 | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | 0.637 |
SCAMP5 | STX4 | ENSP00000355387 | ENSP00000317714 | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.639 |
SCAMP5 | STX6 | ENSP00000355387 | ENSP00000258301 | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | syntaxin 6; Involved in intracellular vesicle trafficking | 0.640 |
SCAMP5 | STX8 | ENSP00000355387 | ENSP00000305255 | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | syntaxin 8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER | 0.585 |
SCAMP5 | VAMP3 | ENSP00000355387 | ENSP00000054666 | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | 0.659 |
SCAMP5 | VAMP4 | ENSP00000355387 | ENSP00000236192 | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule | 0.606 |
SLC9A7 | SCAMP5 | ENSP00000330320 | ENSP00000355387 | solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | 0.715 |
SNAP23 | RAB4A | ENSP00000249647 | ENSP00000355651 | synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.498 |