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MYO1G | myosin IG; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity) (1018 aa) | |||
CUX2 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) (1486 aa) | |||
MYO5C | myosin VC; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues (1742 aa) | |||
CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (286 aa) | |||
PTPN23 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (1636 aa) | |||
IQGAP1 | IQ motif containing GTPase activating protein 1; Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (1657 aa) | |||
PI4KB | phosphatidylinositol 4-kinase, catalytic, beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (828 aa) | |||
IQGAP2 | IQ motif containing GTPase activating protein 2; Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin (1575 aa) | |||
MYO5B | myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) (1848 aa) | |||
ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (300 aa) | |||
CAPZA3 | capping protein (actin filament) muscle Z-line, alpha 3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid (By similarity) (299 aa) | |||
MYO9A | myosin IXA (2548 aa) | |||
POTEF | POTE ankyrin domain family, member F (1075 aa) | |||
CUX1 | cut-like homeobox 1; May be involved in intra-Golgi retrograde transport (1516 aa) | |||
IQGAP3 | IQ motif containing GTPase activating protein 3 (1631 aa) | |||
CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (286 aa) | |||
EFCAB2 | EF-hand calcium binding domain 2 (162 aa) | |||
TPR | translocated promoter region, nuclear basket protein; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates t [...] (2363 aa) | |||
BAG3 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity (575 aa) | |||
MYO9B | myosin IXB; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho (2022 aa) | |||
MYO5A | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation (1855 aa) | |||
POTEJ | POTE ankyrin domain family, member J (1038 aa) | |||
POTEI | POTE ankyrin domain family, member I (1075 aa) | |||
GAS7 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons (476 aa) | |||
POTEE | POTE ankyrin domain family member E (1075 aa) | |||
OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (8678 aa) |