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ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis (592 aa) | |||
FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) (419 aa) | |||
CREBBP | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (2442 aa) | |||
CPOX | coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (454 aa) | |||
PAPSS1 | 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the [...] (624 aa) | |||
TATDN1 | TatD DNase domain containing 1; Putative deoxyribonuclease (By similarity) (297 aa) | |||
ASB6 | ankyrin repeat and SOCS box containing 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (421 aa) | |||
ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa) | |||
MDH2 | malate dehydrogenase 2, NAD (mitochondrial) (338 aa) | |||
AFMID | arylformamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (By similarity) (308 aa) | |||
CS | citrate synthase (466 aa) | |||
UBC | ubiquitin C (685 aa) | |||
ME3 | malic enzyme 3, NADP(+)-dependent, mitochondrial (604 aa) | |||
FH | fumarate hydratase; Also acts as a tumor suppressor (510 aa) | |||
SDHC | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (169 aa) | |||
ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic (572 aa) | |||
HOGA1 | 4-hydroxy-2-oxoglutarate aldolase 1; Catalyzes the final step in the metabolic pathway of hydroxyproline (Probable) (327 aa) | |||
PGM1 | phosphoglucomutase 1 (580 aa) | |||
PIM1 | pim-1 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergi [...] (313 aa) | |||
LDLRAP1 | low density lipoprotein receptor adaptor protein 1; Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalizat [...] (308 aa) | |||
SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (280 aa) | |||
SDHD | succinate dehydrogenase complex, subunit D, integral membrane protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity) (159 aa) | |||
PSAT1 | phosphoserine aminotransferase 1; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) (370 aa) | |||
FAHD1 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (248 aa) | |||
ENSG00000249319 | Uncharacterized protein (293 aa) | |||
CPS1 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell (1506 aa) |