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PARP16 | poly (ADP-ribose) polymerase family, member 16; Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP- ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (323 aa) | |||
TCF3 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (654 aa) | |||
HAS3 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis (553 aa) | |||
TCF12 | transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) (706 aa) | |||
ZNF192 | zinc finger protein 192; May be involved in transcriptional regulation (578 aa) | |||
TCF4 | transcription factor 4 (671 aa) | |||
NRG1 | neuregulin 1 (645 aa) | |||
B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase active in synthesizing a unique carbohydrate structure, GalNAc-beta-1- 3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate (500 aa) | |||
AGMAT | agmatine ureohydrolase (agmatinase) (352 aa) | |||
ZNF445 | zinc finger protein 445; May be involved in transcriptional regulation (1031 aa) | |||
SFRP4 | secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (346 aa) |