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STRINGSTRING
PRTG PRTG DCC DCC TRIM67 TRIM67 PLEKHG4B PLEKHG4B TRIO TRIO SESTD1 SESTD1 NEO1 NEO1 KALRN KALRN IGDCC3 IGDCC3 MCF2L2 MCF2L2 MCF2 MCF2 FNDC1 FNDC1 IGDCC4 IGDCC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
KALRNkalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (1663 aa)
NEO1neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues (1461 aa)
PLEKHG4Bpleckstrin homology domain containing, family G (with RhoGef domain) member 4B (1271 aa)
FNDC1fibronectin type III domain containing 1 (1894 aa)
IGDCC4immunoglobulin superfamily, DCC subclass, member 4 (1250 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) (1114 aa)
IGDCC3immunoglobulin superfamily, DCC subclass, member 3 (814 aa)
TRIOtrio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth (3097 aa)
TRIM67tripartite motif containing 67 (783 aa)
PRTGprotogenin; May play a role in anteroposterior axis elongation (By similarity) (1150 aa)
DCCdeleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (1447 aa)
SESTD1SEC14 and spectrin domains 1; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 (696 aa)
MCF2MCF.2 cell line derived transforming sequence (1001 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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