node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCC | KALRN | ENSP00000389140 | ENSP00000240874 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity | 0.711 |
DCC | MCF2 | ENSP00000389140 | ENSP00000430276 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | MCF.2 cell line derived transforming sequence | 0.498 |
DCC | MCF2L2 | ENSP00000389140 | ENSP00000328118 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.498 |
DCC | NEO1 | ENSP00000389140 | ENSP00000261908 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues | 0.905 |
DCC | PLEKHG4B | ENSP00000389140 | ENSP00000283426 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | 0.577 |
DCC | SESTD1 | ENSP00000389140 | ENSP00000415332 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | SEC14 and spectrin domains 1; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 | 0.488 |
DCC | TRIM67 | ENSP00000389140 | ENSP00000355613 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | tripartite motif containing 67 | 0.771 |
DCC | TRIO | ENSP00000389140 | ENSP00000339299 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | trio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth | 0.943 |
FNDC1 | KALRN | ENSP00000297267 | ENSP00000240874 | fibronectin type III domain containing 1 | kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity | 0.488 |
FNDC1 | MCF2 | ENSP00000297267 | ENSP00000430276 | fibronectin type III domain containing 1 | MCF.2 cell line derived transforming sequence | 0.488 |
FNDC1 | MCF2L2 | ENSP00000297267 | ENSP00000328118 | fibronectin type III domain containing 1 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.488 |
FNDC1 | PLEKHG4B | ENSP00000297267 | ENSP00000283426 | fibronectin type III domain containing 1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | 0.577 |
FNDC1 | SESTD1 | ENSP00000297267 | ENSP00000415332 | fibronectin type III domain containing 1 | SEC14 and spectrin domains 1; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 | 0.488 |
FNDC1 | TRIM67 | ENSP00000297267 | ENSP00000355613 | fibronectin type III domain containing 1 | tripartite motif containing 67 | 0.448 |
FNDC1 | TRIO | ENSP00000297267 | ENSP00000339299 | fibronectin type III domain containing 1 | trio Rho guanine nucleotide exchange factor; Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth | 0.515 |
IGDCC3 | KALRN | ENSP00000332773 | ENSP00000240874 | immunoglobulin superfamily, DCC subclass, member 3 | kalirin, RhoGEF kinase; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity | 0.680 |
IGDCC3 | MCF2 | ENSP00000332773 | ENSP00000430276 | immunoglobulin superfamily, DCC subclass, member 3 | MCF.2 cell line derived transforming sequence | 0.575 |
IGDCC3 | MCF2L2 | ENSP00000332773 | ENSP00000328118 | immunoglobulin superfamily, DCC subclass, member 3 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.575 |
IGDCC3 | PLEKHG4B | ENSP00000332773 | ENSP00000283426 | immunoglobulin superfamily, DCC subclass, member 3 | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | 0.658 |
IGDCC3 | SESTD1 | ENSP00000332773 | ENSP00000415332 | immunoglobulin superfamily, DCC subclass, member 3 | SEC14 and spectrin domains 1; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 | 0.575 |