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ENSG00000258728 ENSG00000258728 IL9R IL9R IL13RA1 IL13RA1 CNTFR CNTFR IL6ST IL6ST IL5RA IL5RA IL4R IL4R IL2RB IL2RB IL2RA IL2RA IL3RA IL3RA CSF2RB CSF2RB EPOR EPOR IL7R IL7R IL20 IL20 PRLR PRLR CSF2RA CSF2RA IFNAR2 IFNAR2 LEPR LEPR IL10RA IL10RA IFNGR1 IFNGR1 IL12RB1 IL12RB1 IL23R IL23R IL20RB IL20RB IL22RA2 IL22RA2 IL12RB2 IL12RB2 IL20RA IL20RA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
IL4Rinterleukin 4 receptor (825 aa)
IL2RBinterleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 (551 aa)
EPORerythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase (508 aa)
IL10RAinterleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity (578 aa)
CNTFRciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity (372 aa)
IL9Rinterleukin 9 receptor; This is a receptor for interleukin-9 (521 aa)
IL5RAinterleukin 5 receptor, alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5 (420 aa)
IL12RB2interleukin 12 receptor, beta 2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production (862 aa)
IL22RA2interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses (263 aa)
IL7Rinterleukin 7 receptor (459 aa)
IL20RAinterleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (553 aa)
IL23Rinterleukin 23 receptor (629 aa)
IL3RAinterleukin 3 receptor, alpha (low affinity); This is a receptor for interleukin-3 (378 aa)
IL20RBinterleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24 (311 aa)
LEPRleptin receptor; Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity) (1165 aa)
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events (918 aa)
IFNAR2interferon (alpha, beta and omega) receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity (515 aa)
IL20interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 (176 aa)
IFNGR1interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer (489 aa)
IL13RA1interleukin 13 receptor, alpha 1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity (427 aa)
IL2RAinterleukin 2 receptor, alpha; Receptor for interleukin-2 (272 aa)
PRLRprolactin receptor (622 aa)
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor (897 aa)
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (434 aa)
IL12RB1interleukin 12 receptor, beta 1; Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade (662 aa)
ENSG00000258728Uncharacterized protein (280 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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