| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ELAVL1 | ILF3 | ENSP00000385269 | ENSP00000404121 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | interleukin enhancer binding factor 3, 90kDa | 0.537 |
| ELAVL1 | UBC | ENSP00000385269 | ENSP00000344818 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | ubiquitin C | 0.998 |
| ILF3 | ELAVL1 | ENSP00000404121 | ENSP00000385269 | interleukin enhancer binding factor 3, 90kDa | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.537 |
| ILF3 | NUCKS1 | ENSP00000404121 | ENSP00000356110 | interleukin enhancer binding factor 3, 90kDa | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.660 |
| ILF3 | UBC | ENSP00000404121 | ENSP00000344818 | interleukin enhancer binding factor 3, 90kDa | ubiquitin C | 0.969 |
| NUCKS1 | ILF3 | ENSP00000356110 | ENSP00000404121 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | interleukin enhancer binding factor 3, 90kDa | 0.660 |
| NUCKS1 | ORC2 | ENSP00000356110 | ENSP00000234296 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | origin recognition complex, subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication | 0.644 |
| NUCKS1 | PRCP | ENSP00000356110 | ENSP00000377055 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | prolylcarboxypeptidase (angiotensinase C); Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH | 0.401 |
| NUCKS1 | RBM42 | ENSP00000356110 | ENSP00000262633 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | RNA binding motif protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA (By similarity) | 0.644 |
| NUCKS1 | RBMX | ENSP00000356110 | ENSP00000359645 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | 0.644 |
| NUCKS1 | UBC | ENSP00000356110 | ENSP00000344818 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | ubiquitin C | 0.483 |
| ORC2 | NUCKS1 | ENSP00000234296 | ENSP00000356110 | origin recognition complex, subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.644 |
| ORC2 | UBC | ENSP00000234296 | ENSP00000344818 | origin recognition complex, subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication | ubiquitin C | 0.926 |
| PRCP | NUCKS1 | ENSP00000377055 | ENSP00000356110 | prolylcarboxypeptidase (angiotensinase C); Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.401 |
| PRCP | UBC | ENSP00000377055 | ENSP00000344818 | prolylcarboxypeptidase (angiotensinase C); Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH | ubiquitin C | 0.620 |
| RBM42 | NUCKS1 | ENSP00000262633 | ENSP00000356110 | RNA binding motif protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA (By similarity) | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.644 |
| RBM42 | UBC | ENSP00000262633 | ENSP00000344818 | RNA binding motif protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA (By similarity) | ubiquitin C | 0.721 |
| RBMX | NUCKS1 | ENSP00000359645 | ENSP00000356110 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.644 |
| RBMX | UBC | ENSP00000359645 | ENSP00000344818 | RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...] | ubiquitin C | 0.984 |
| UBC | ELAVL1 | ENSP00000344818 | ENSP00000385269 | ubiquitin C | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | 0.998 |
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