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STRINGSTRING
AGAP8 AGAP8 GPCPD1 GPCPD1 NPLOC4 NPLOC4 NAP1L5 NAP1L5 ARC ARC PRKCI PRKCI NOL3 NOL3 PRKCZ PRKCZ RAB11B RAB11B NAP1L1 NAP1L1 NAP1L4 NAP1L4 ETNK2 ETNK2 PRKACG PRKACG DOLK DOLK AGXT2L1 AGXT2L1 NAP1L3 NAP1L3 PGS1 PGS1 PLD1 PLD1 PLD6 PLD6 PCYT2 PCYT2 AGAP1 AGAP1 PLD2 PLD2 SEC14L5 SEC14L5 NAP1L6 NAP1L6 NAP1L2 NAP1L2 SEC14L1 SEC14L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SEC14L5SEC14-like 5 (S. cerevisiae) (696 aa)
NAP1L1nucleosome assembly protein 1-like 1; May be involved in modulating chromatin formation and contribute to regulation of cell proliferation (391 aa)
PGS1phosphatidylglycerophosphate synthase 1; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin (By similarity) (556 aa)
PLD2phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (933 aa)
NOL3nucleolar protein 3 (apoptosis repressor with CARD domain); Isoform 1 may be involved in RNA splicing (208 aa)
PRKCIprotein kinase C, iota; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a [...] (596 aa)
AGXT2L1alanine-glyoxylate aminotransferase 2-like 1; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde (499 aa)
AGAP1ArfGAP with GTPase domain, ankyrin repeat and PH domain 1; GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system (857 aa)
PLD6phospholipase D family, member 6; Regulates mitochondrial shape through facilitating mitochondrial fusion. During spermatogenesis, plays a critical role in PIWI-interacting RNA (piRNA) biogenesis (By similarity). piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving e [...] (252 aa)
NAP1L5nucleosome assembly protein 1-like 5 (182 aa)
NPLOC4nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) (608 aa)
RAB11BRAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) (218 aa)
PLD1phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) (1074 aa)
ARCactivity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (396 aa)
ETNK2ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity) (386 aa)
DOLKdolichol kinase; Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors (By similarity) (538 aa)
NAP1L3nucleosome assembly protein 1-like 3 (506 aa)
NAP1L2nucleosome assembly protein 1-like 2; Acidic protein which may be involved in interactions with other proteins or DNA (By similarity) (460 aa)
NAP1L6nucleosome assembly protein 1-like 6 (107 aa)
PRKACGprotein kinase, cAMP-dependent, catalytic, gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus (351 aa)
PRKCZprotein kinase C, zeta; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required [...] (592 aa)
GPCPD1glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae); May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity (By similarity) (672 aa)
NAP1L4nucleosome assembly protein 1-like 4 (375 aa)
SEC14L1SEC14-like 1 (S. cerevisiae) (719 aa)
AGAP8ArfGAP with GTPase domain, ankyrin repeat and PH domain 8; Putative GTPase-activating protein (Potential) (663 aa)
PCYT2phosphate cytidylyltransferase 2, ethanolamine; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine (407 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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