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HRH2 HRH2 DRD1 DRD1 CALCA CALCA DRD5 DRD5 CALCB CALCB MC2R MC2R ADCY1 ADCY1 VIP VIP ADRB3 ADRB3 MC5R MC5R PTGIR PTGIR HTR4 HTR4 ADM ADM GNG2 GNG2 ADORA2B ADORA2B PTGER4 PTGER4 GNAS GNAS HTR7 HTR7 CALCR CALCR CRHR2 CRHR2 NPSR1 NPSR1 ADCY2 ADCY2 ADRB1 ADRB1 GIP GIP GLP1R GLP1R RXFP2 RXFP2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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ADMadrenomedullin; AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels (185 aa)
PTGIRprostaglandin I2 (prostacyclin) receptor (IP); Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase (386 aa)
ADCY1adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning (1119 aa)
RXFP2relaxin/insulin-like family peptide receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (754 aa)
PTGER4prostaglandin E receptor 4 (subtype EP4); Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (488 aa)
ADORA2Badenosine A2b receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (332 aa)
DRD5dopamine receptor D5; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase (477 aa)
MC5Rmelanocortin 5 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins (325 aa)
DRD1dopamine receptor D1; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase (446 aa)
CALCAcalcitonin-related polypeptide alpha; Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones (141 aa)
MC2Rmelanocortin 2 receptor (adrenocorticotropic hormone); Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (297 aa)
GNG2guanine nucleotide binding protein (G protein), gamma 2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) (71 aa)
HTR75-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (479 aa)
CRHR2corticotropin releasing hormone receptor 2; This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (438 aa)
ADCY2adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (1091 aa)
ADRB3adrenoceptor beta 3; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis (408 aa)
CALCBcalcitonin-related polypeptide beta; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (127 aa)
GIPgastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion (153 aa)
CALCRcalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin (508 aa)
NPSR1neuropeptide S receptor 1 (377 aa)
HTR45-hydroxytryptamine (serotonin) receptor 4, G protein-coupled (428 aa)
VIPvasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (170 aa)
ADRB1adrenoceptor beta 1; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity (477 aa)
GNASGNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) (1037 aa)
GLP1Rglucagon-like peptide 1 receptor; This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (463 aa)
HRH2histamine receptor H2; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity) (397 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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