node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000255819 | KLRK1 | ENSP00000455951 | ENSP00000240618 | NKG2-D type II integral membrane protein | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | 0.576 |
ENSG00000255819 | RAET1G | ENSP00000455951 | ENSP00000356329 | NKG2-D type II integral membrane protein | retinoic acid early transcript 1G; Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor | 0.576 |
KLRK1 | ENSG00000255819 | ENSP00000240618 | ENSP00000455951 | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | NKG2-D type II integral membrane protein | 0.576 |
KLRK1 | RAET1G | ENSP00000240618 | ENSP00000356329 | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | retinoic acid early transcript 1G; Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor | 0.939 |
KLRK1 | ULBP1 | ENSP00000240618 | ENSP00000229708 | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] | 0.905 |
RAET1G | ENSG00000255819 | ENSP00000356329 | ENSP00000455951 | retinoic acid early transcript 1G; Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor | NKG2-D type II integral membrane protein | 0.576 |
RAET1G | KLRK1 | ENSP00000356329 | ENSP00000240618 | retinoic acid early transcript 1G; Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | 0.939 |
RAET1G | ULBP1 | ENSP00000356329 | ENSP00000229708 | retinoic acid early transcript 1G; Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor | UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] | 0.588 |
ULBP1 | KLRK1 | ENSP00000229708 | ENSP00000240618 | UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] | killer cell lectin-like receptor subfamily K, member 1; Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes | 0.905 |
ULBP1 | RAET1G | ENSP00000229708 | ENSP00000356329 | UL16 binding protein 1; Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. [...] | retinoic acid early transcript 1G; Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor | 0.588 |