11 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	CD8A	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains (235 aa)
	AZGP1	alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids (298 aa)
	ILK	integrin-linked kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (452 aa)
	HLA-G	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells (338 aa)
	MR1	major histocompatibility complex, class I-related (341 aa)
	FATE1	fetal and adult testis expressed 1 (183 aa)
	HLA-C	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa)
	HLA-A	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa)
	HLA-B	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) (362 aa)
	HFE	hemochromatosis (348 aa)
	B2M	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) (119 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AZGP1	B2M	ENSP00000292401	ENSP00000452780	alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.610
AZGP1	MR1	ENSP00000292401	ENSP00000356552	alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids	major histocompatibility complex, class I-related	0.402
B2M	AZGP1	ENSP00000452780	ENSP00000292401	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	alpha-2-glycoprotein 1, zinc-binding; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids	0.610
B2M	CD8A	ENSP00000452780	ENSP00000283635	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	0.998
B2M	HFE	ENSP00000452780	ENSP00000417404	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	hemochromatosis	0.998
B2M	HLA-A	ENSP00000452780	ENSP00000366005	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.998
B2M	HLA-B	ENSP00000452780	ENSP00000399168	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.999
B2M	HLA-C	ENSP00000452780	ENSP00000365402	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.986
B2M	HLA-G	ENSP00000452780	ENSP00000353472	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.924
B2M	MR1	ENSP00000452780	ENSP00000356552	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I-related	0.985
CD8A	B2M	ENSP00000283635	ENSP00000452780	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.998
CD8A	HLA-A	ENSP00000283635	ENSP00000366005	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.987
CD8A	HLA-B	ENSP00000283635	ENSP00000399168	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.992
CD8A	HLA-C	ENSP00000283635	ENSP00000365402	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.992
CD8A	HLA-G	ENSP00000283635	ENSP00000353472	CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.967
FATE1	MR1	ENSP00000359375	ENSP00000356552	fetal and adult testis expressed 1	major histocompatibility complex, class I-related	0.400
HFE	B2M	ENSP00000417404	ENSP00000452780	hemochromatosis	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.998
HFE	HLA-A	ENSP00000417404	ENSP00000366005	hemochromatosis	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.559
HFE	HLA-B	ENSP00000417404	ENSP00000399168	hemochromatosis	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.561
HFE	HLA-C	ENSP00000417404	ENSP00000365402	hemochromatosis	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.544

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