node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACBD6 | UBC | ENSP00000356567 | ENSP00000344818 | acyl-CoA binding domain containing 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18-1-CoA, lower affinity for unsaturated C20-4-CoA, and very weak affinity for saturated C16-0- CoA. Does not bind fatty acids | ubiquitin C | 0.747 |
CDIPT | CRLS1 | ENSP00000219789 | ENSP00000368140 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme | cardiolipin synthase 1; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol | 0.902 |
CDIPT | UBC | ENSP00000219789 | ENSP00000344818 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme | ubiquitin C | 0.746 |
CRLS1 | CDIPT | ENSP00000368140 | ENSP00000219789 | cardiolipin synthase 1; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme | 0.902 |
CRLS1 | TAZ | ENSP00000368140 | ENSP00000299328 | cardiolipin synthase 1; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol | tafazzin | 0.496 |
IKBKG | UBC | ENSP00000358622 | ENSP00000344818 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...] | ubiquitin C | 0.999 |
NMT1 | UBC | ENSP00000258960 | ENSP00000344818 | N-myristoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity) | ubiquitin C | 0.821 |
PLD1 | UBC | ENSP00000342793 | ENSP00000344818 | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | ubiquitin C | 0.906 |
PLD2 | UBC | ENSP00000263088 | ENSP00000344818 | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | ubiquitin C | 0.919 |
SUMO2 | UBC | ENSP00000405965 | ENSP00000344818 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | ubiquitin C | 0.999 |
TAZ | CRLS1 | ENSP00000299328 | ENSP00000368140 | tafazzin | cardiolipin synthase 1; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol | 0.496 |
TAZ | UBC | ENSP00000299328 | ENSP00000344818 | tafazzin | ubiquitin C | 0.618 |
UBC | ACBD6 | ENSP00000344818 | ENSP00000356567 | ubiquitin C | acyl-CoA binding domain containing 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18-1-CoA, lower affinity for unsaturated C20-4-CoA, and very weak affinity for saturated C16-0- CoA. Does not bind fatty acids | 0.747 |
UBC | CDIPT | ENSP00000344818 | ENSP00000219789 | ubiquitin C | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme | 0.746 |
UBC | IKBKG | ENSP00000344818 | ENSP00000358622 | ubiquitin C | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either ’Lys-63’- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Als [...] | 0.999 |
UBC | NMT1 | ENSP00000344818 | ENSP00000258960 | ubiquitin C | N-myristoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity) | 0.821 |
UBC | PLD1 | ENSP00000344818 | ENSP00000342793 | ubiquitin C | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | 0.906 |
UBC | PLD2 | ENSP00000344818 | ENSP00000263088 | ubiquitin C | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | 0.919 |
UBC | SUMO2 | ENSP00000344818 | ENSP00000405965 | ubiquitin C | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.999 |
UBC | TAZ | ENSP00000344818 | ENSP00000299328 | ubiquitin C | tafazzin | 0.618 |