node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJA3 | UBC | ENSP00000262375 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | ubiquitin C | 0.758 |
DNAJC16 | UBC | ENSP00000365007 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily C, member 16 | ubiquitin C | 0.541 |
DNAJC3 | UBC | ENSP00000365991 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | ubiquitin C | 0.752 |
DNAJC5 | UBC | ENSP00000354111 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | ubiquitin C | 0.905 |
NAGLU | UBC | ENSP00000225927 | ENSP00000344818 | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | ubiquitin C | 0.620 |
TOR1A | TOR1AIP1 | ENSP00000345719 | ENSP00000393292 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | torsin A interacting protein 1 | 0.988 |
TOR1A | TOR3A | ENSP00000345719 | ENSP00000356599 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | torsin family 3, member A | 0.588 |
TOR1A | UBC | ENSP00000345719 | ENSP00000344818 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | ubiquitin C | 0.496 |
TOR1AIP1 | TOR1A | ENSP00000393292 | ENSP00000345719 | torsin A interacting protein 1 | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.988 |
TOR1AIP1 | TOR3A | ENSP00000393292 | ENSP00000356599 | torsin A interacting protein 1 | torsin family 3, member A | 0.812 |
TOR1AIP1 | UBC | ENSP00000393292 | ENSP00000344818 | torsin A interacting protein 1 | ubiquitin C | 0.849 |
TOR3A | TOR1A | ENSP00000356599 | ENSP00000345719 | torsin family 3, member A | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.588 |
TOR3A | TOR1AIP1 | ENSP00000356599 | ENSP00000393292 | torsin family 3, member A | torsin A interacting protein 1 | 0.812 |
TOR3A | UBC | ENSP00000356599 | ENSP00000344818 | torsin family 3, member A | ubiquitin C | 0.483 |
UBC | DNAJA3 | ENSP00000344818 | ENSP00000262375 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | 0.758 |
UBC | DNAJC16 | ENSP00000344818 | ENSP00000365007 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily C, member 16 | 0.541 |
UBC | DNAJC3 | ENSP00000344818 | ENSP00000365991 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily C, member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity | 0.752 |
UBC | DNAJC5 | ENSP00000344818 | ENSP00000354111 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | 0.905 |
UBC | NAGLU | ENSP00000344818 | ENSP00000225927 | ubiquitin C | N-acetylglucosaminidase, alpha; Involved in the degradation of heparan sulfate | 0.620 |
UBC | TOR1A | ENSP00000344818 | ENSP00000345719 | ubiquitin C | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.496 |