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STRINGSTRING
CCNI CCNI CCNB3 CCNB3 NFKBIB NFKBIB CCNG1 CCNG1 CCNB2 CCNB2 CCNG2 CCNG2 ARF6 ARF6 CCNB1 CCNB1 RAP1A RAP1A CCNF CCNF RAP1B RAP1B CCNA2 CCNA2 CNTD2 CNTD2 UBC UBC CCNA1 CCNA1 CCNI2 CCNI2 CTAGE5 CTAGE5 RASAL2 RASAL2 YWHAG YWHAG CCNO CCNO CSNK1E CSNK1E SH3KBP1 SH3KBP1 CSNK1A1 CSNK1A1 CIRH1A CIRH1A ARL15 ARL15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CCNIcyclin I (377 aa)
RAP1BRAP1B, member of RAS oncogene family (184 aa)
CCNA1cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells (465 aa)
CCNB1cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition (433 aa)
CCNA2cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions (432 aa)
CCNB3cyclin B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (1395 aa)
CTAGE5CTAGE family, member 5 (804 aa)
CCNOcyclin O (350 aa)
CCNB2cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition (398 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension (175 aa)
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (247 aa)
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation (356 aa)
CCNG2cyclin G2; May play a role in growth regulation and in negative regulation of cell cycle progession (344 aa)
CIRH1Acirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (686 aa)
CCNG1cyclin G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity) (295 aa)
UBCubiquitin C (685 aa)
RAP1ARAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner (184 aa)
CSNK1Ecasein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation (416 aa)
RASAL2RAS protein activator like 2; Inhibitory regulator of the Ras-cyclic AMP pathway (1280 aa)
CCNI2cyclin I family, member 2 (369 aa)
CCNFcyclin F; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (786 aa)
SH3KBP1SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] (665 aa)
CNTD2cyclin N-terminal domain containing 2 (307 aa)
CSNK1A1casein kinase 1, alpha 1 (365 aa)
ARL15ADP-ribosylation factor-like 15 (204 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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